Sex and the development of Alzheimer's disease

CJ Pike - Journal of neuroscience research, 2017 - Wiley Online Library
Men and women exhibit differences in the development and progression of Alzheimer's
disease (AD). The factors underlying the sex differences in AD are not well understood. This …

Endogenous and exogenous estrogen exposures: how women's reproductive health can drive brain aging and inform Alzheimer's prevention

S Jett, N Malviya, E Schelbaum, G Jang… - Frontiers in Aging …, 2022 - frontiersin.org
After advanced age, female sex is the major risk factor for late-onset Alzheimer's disease
(AD), the most common cause of dementia affecting over 24 million people worldwide. The …

Sex differences in Alzheimer's disease and common neuropathologies of aging

S Oveisgharan, Z Arvanitakis, L Yu, J Farfel… - Acta …, 2018 - Springer
Alzheimer's dementia is significantly more common in women than in men. However, few
pathological studies have addressed sex difference in Alzheimer's disease (AD) and other …

Sex-specific association of apolipoprotein E with cerebrospinal fluid levels of tau

TJ Hohman, L Dumitrescu, LL Barnes… - JAMA …, 2018 - jamanetwork.com
Importance The strongest genetic risk factor for Alzheimer disease (AD), the apolipoprotein
E (APOE) gene, has a stronger association among women compared with men. Yet limited …

Sex differences in the association between AD biomarkers and cognitive decline

MEI Koran, M Wagener, TJ Hohman… - Brain imaging and …, 2017 - Springer
Women are disproportionately affected by Alzheimer's disease (AD) in terms of both disease
prevalence and severity. Previous autopsy work has suggested that, in the presence of AD …

Cognition, mood and sleep in menopausal transition: the role of menopause hormone therapy

G Gava, I Orsili, S Alvisi, I Mancini, R Seracchioli… - Medicina, 2019 - mdpi.com
During the menopausal transition, which begins four to six years before cessation of
menses, middle-aged women experience a progressive change in ovarian activity and a …

[图书][B] The female brain

L Brizendine - 2007 - books.google.com
Since Dr. Brizendine wrote The Female Brain ten years ago, the response has been
overwhelming. This New York Times bestseller has been translated into more than thirty …

Is hormone replacement therapy a risk factor or a therapeutic option for Alzheimer's disease?

ZB Mills, RLM Faull, A Kwakowsky - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for
more than half of all dementia cases in the elderly. Interestingly, the clinical manifestations of …

Systematic review and meta-analysis of the effects of menopause hormone therapy on risk of Alzheimer's disease and dementia

M Nerattini, S Jett, C Andy, C Carlton… - Frontiers in aging …, 2023 - frontiersin.org
Introduction Despite a large preclinical literature demonstrating neuroprotective effects of
estrogen, use of menopausal hormone therapy (HT) for Alzheimer's disease (AD) risk …

Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications

DW Brann, K Dhandapani, C Wakade, VB Mahesh… - Steroids, 2007 - Elsevier
Estrogen is an important hormone signal that regulates multiple tissues and functions in the
body. This review focuses on the neurotrophic and neuroprotective actions of estrogen in the …