In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells
through an 'inside out'signalling process whereby structurally diverse phosphoantigen (pAg) …

In the past two decades, adeno-associated virus (AAV) vector manufacturing has made
remarkable advancements to meet large-scale production demands for preclinical and …

Farnesylation and carboxymethylation of KRAS4b (Kirsten rat sarcoma isoform 4b) are
essential for its interaction with the plasma membrane where KRAS-mediated signaling …

Analytical ultracentrifugation (AUC) is a critical analytical tool supporting the development
and manufacture of protein therapeutics. AUC is routinely used as an assay orthogonal to …

The HIV-1 capsid protein plays a crucial role in viral infectivity, assembling into a cone that
encloses the viral RNA. In the mature virion, the N-terminal domain of the capsid protein …

The HIV-1 virion structural polyprotein, Gag, is directed to particle assembly sites at the
plasma membrane by its N-terminal matrix (MA) domain. MA also binds to host tRNAs. To …

Analytical ultracentrifugation has played a dominant role not only in introducing us to the
world of macromolecules, but has also played a dominant role in establishing and …

Alterations in glycosylation cause the emergence of tumor-associated carbohydrate
antigens (TACAs) during tumorigenesis. Truncation of O-glycans reveals the Thomsen …

Selective packaging of HIV-1 genomic RNA (gRNA) requires the presence of a cis-acting
RNA element called the 'packaging signal'(Ψ). However, the mechanism by which Ψ …

Autofluorescence properties of amyloid fibrils are of much interest but, to date, the attention
has been given mostly to one-photon excited fluorescence (1PEF), while the two-photon …