Trimethylation of histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2
(PRC2) is essential for transcriptional silencing of Polycomb target genes, whereas …

Highlights•CBP and p300 (KAT3s) interact with dozens of TFs and acetylate hundreds of
substrates.•KAT3s have both unique and overlapping functions during neural …

The number of genetic syndromes associated with intellectual disability that are caused by
mutations in genes encoding chromatin-modifying enzymes has sharply risen in the last …

Trithorax (TRX) antagonizes epigenetic silencing by Polycomb group (PcG) proteins,
stimulates enhancer-dependent transcription, and establishes a 'cellular memory'of active …

The evolution of color vision is often studied through the lens of receptor gain relative to an
ancestor with fewer spectral classes of photoreceptor. For instance, in Heliconius butterflies …

Many Wnts influence cell behavior by a conserved signaling cascade that promotes the
stabilization and nuclear accumulation of β‐catenin (β‐cat), which then associates with TCF …

Pruning that selectively removes unnecessary axons/dendrites is crucial for sculpting neural
circuits during development. During Drosophila metamorphosis, dendritic arborization …

Background The progressive neurodegenerative disorder Alzheimer's disease (AD)
manifests as loss of cognitive functions, and finally leads to death of the affected individual …

In Drosophila, defense against foreign pathogens is mediated by an effective innate immune
system, the cellular arm of which is composed of circulating hemocytes that engulf bacteria …

Root rot diseases of plant are accountable for crop yield losses. Biological control of this
disease is considered a feasible alternative and eco-friendly method. The root rot …