Yeast Sub1 and human PC4, two DNA-binding proteins, were originally identified as
transcriptional coactivators with a role during transcription preinitiation/initiation. Indeed …

Evolutionarily conserved kinases and phosphatases regulate RNA polymerase II (RNAPII)
transcript synthesis by modifying the phosphorylation status of the carboxyl-terminal domain …

Abstract The Rpb4 and Rpb7 subunits of eukaryotic RNA polymerase II (RNAPII) participate
in a variety of processes from transcription, DNA repair, mRNA export and decay, to …

Objective Hepatitis D virus (HDV) is a circular RNA virus coinfecting hepatocytes with
hepatitis B virus. Chronic hepatitis D results in severe liver disease and an increased risk of …

The marine, bloom-forming dinoflagellate Prorocentrum cordatum CCMP 1329 (formerly P.
minimum) has a genome atypical of eukaryotes, with a large size of~ 4.15 Gbp, organized in …

Gene expression is a complex phenomenon that depends on multiple protein complexes,
including RNA polymerases (RNA pols). In eukaryotes, bacteria, and archaea, RNA pols are …

Biogenesis of messenger RNA is critically influenced by the phosphorylation state of the
carboxy-terminal domain (CTD) in the largest RNA polymerase II (RNAPII) subunit. Several …

In eukaryotes, cellular RNAs are produced by three nuclear RNA polymerases (RNAPI, II,
and III), which are multisubunit complexes. They share structural and functional features …

Abstract DNA-directed RNA polymerase II (pol II) is composed of ten core and two
dissociable subunits. The dissociable subcomplex is a heterodimer of Rpb4/Polr2d and …

Rtr1 is an RNA polymerase II (RNA pol II) CTD-phosphatase that influences gene
expression during the transition from transcription initiation to elongation and during …