Diabetes is a growing global health concern, as is obesity. Diabetes and obesity are
intrinsically linked: obesity increases the risk of diabetes and also contributes to disease …

Insulin production by the pancreas follows a basic pattern where basal levels of insulin are
secreted during fasting periods, with prandial increases in insulin associated with food …

Summary Background Oral insulin 338 (I338) is a long-acting, basal insulin analogue
formulated in a tablet with the absorption-enhancer sodium caprate. We investigated the …

Introduction Hypoglycemia is the most common adverse effect of diabetes therapy,
particularly insulin treatment. Hypoglycemia is associated with considerable clinical and …

• De streefwaarden van het HbA1c zijn aangepast. De intensiteit van de
diabetesbehandeling, leeftijd van de patiënt en de diabetesduur zijn factoren die van …

Insulin remains the most effective and consistent means of controlling blood glucose levels
in diabetes. Since 1946, neutral protamine Hagedorn (NPH) has been the predominant …

The hyperinsulinaemic‐euglycaemic glucose clamp has always been regarded as the “gold
standard” for the assessment of pharmacodynamic (PD) properties of insulin preparations; …

Background: Basal insulin analogues aim for protracted glycemic control with minimal
adverse effects. Purpose: To assess the comparative efficacy and safety of basal insulin …

Objective To compare the efficacy and safety of a concentrated formulation of insulin
glargine (Gla-300) with other basal insulin therapies in patients with type 2 diabetes mellitus …

Objective To evaluate real-world treatment persistence among patients with type 2 diabetes
mellitus (T2DM) initiating treatment with insulin. Methods Patient-level data were pooled …