Local and systemic mechanisms that control the hair follicle stem cell niche

B Zhang, T Chen - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Hair follicles are essential appendages of the mammalian skin, as hair performs vital
functions of protection, thermoregulation and sensation. Hair follicles harbour exceptional …

The sympathetic nervous system in development and disease

E Scott-Solomon, E Boehm, R Kuruvilla - Nature Reviews …, 2021 - nature.com
The sympathetic nervous system prepares the body for 'fight or flight'responses and
maintains homeostasis during daily activities such as exercise, eating a meal or regulation …

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

DH Brann, T Tsukahara, C Weinreb, M Lipovsek… - Science …, 2020 - science.org
Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A
key question is whether SARS-CoV-2 (CoV-2)–the causal agent in COVID-19–affects …

[HTML][HTML] Molecular architecture of the mouse nervous system

A Zeisel, H Hochgerner, P Lönnerberg, A Johnsson… - Cell, 2018 - cell.com
The mammalian nervous system executes complex behaviors controlled by specialized,
precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a …

[HTML][HTML] Somatotopic organization and intensity dependence in driving distinct NPY-expressing sympathetic pathways by electroacupuncture

S Liu, ZF Wang, YS Su, RS Ray, XH Jing, YQ Wang… - Neuron, 2020 - cell.com
The neuroanatomical basis behind acupuncture practice is still poorly understood. Here, we
used intersectional genetic strategy to ablate NPY+ noradrenergic neurons and/or adrenal …

[HTML][HTML] Genetic mapping of cell type specificity for complex traits

K Watanabe, M Umićević Mirkov, CA de Leeuw… - Nature …, 2019 - nature.com
Single-cell RNA sequencing (scRNA-seq) data allows to create cell type specific
transcriptome profiles. Such profiles can be aligned with genome-wide association studies …

Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease

KA Ziegler, A Ahles, A Dueck, D Esfandyari, P Pichler… - Science, 2023 - science.org
Disruption of the physiologic sleep-wake cycle and low melatonin levels frequently
accompany cardiac disease, yet the underlying mechanism has remained enigmatic …

γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis

B Hu, C Jin, X Zeng, JM Resch, MP Jedrychowski… - Nature, 2020 - nature.com
The sympathetic nervous system innervates peripheral organs to regulate their function and
maintain homeostasis, whereas target cells also produce neurotrophic factors to promote …

[HTML][HTML] Targeting peripheral somatosensory neurons to improve tactile-related phenotypes in ASD models

LL Orefice, JR Mosko, DT Morency, MF Wells… - Cell, 2019 - cell.com
Somatosensory over-reactivity is common among patients with autism spectrum disorders
(ASDs) and is hypothesized to contribute to core ASD behaviors. However, effective …

[HTML][HTML] Cell types promoting goosebumps form a niche to regulate hair follicle stem cells

Y Shwartz, M Gonzalez-Celeiro, CL Chen, HA Pasolli… - Cell, 2020 - cell.com
Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili
muscle (APM), and the sympathetic nerve, providing a model to study interactions across …