PPARs and molecular mechanisms of transrepression
In the last few years, PPARs have emerged as key regulators of inflammatory and immune
responses. However, the mechanistic basis of the anti-inflammatory effects of peroxisome …
responses. However, the mechanistic basis of the anti-inflammatory effects of peroxisome …
Mouse models for atherosclerosis and pharmaceutical modifiers
S Zadelaar, R Kleemann, L Verschuren… - … , and vascular biology, 2007 - Am Heart Assoc
Atherosclerosis is a multifactorial highly-complex disease with numerous etiologies that
work synergistically to promote lesion development. The ability to develop preventive and …
work synergistically to promote lesion development. The ability to develop preventive and …
Achievement of dual low-density lipoprotein cholesterol and high-sensitivity C-reactive protein targets more frequent with the addition of ezetimibe to simvastatin and …
Background—Statins lower low-density lipoprotein cholesterol (LDL-C) and high-sensitivity
C-reactive protein (hs-CRP); addition of ezetimibe to statins further reduces LDL-C and hs …
C-reactive protein (hs-CRP); addition of ezetimibe to statins further reduces LDL-C and hs …
[HTML][HTML] Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
Monocytes participate critically in atherosclerosis. There are 2 major subsets expressing
different chemokine receptor patterns: CCR2+ CX3CR1+ Ly-6Chi and CCR2–CX3CR1++ …
different chemokine receptor patterns: CCR2+ CX3CR1+ Ly-6Chi and CCR2–CX3CR1++ …
Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models
OBJECTIVE: Polyphenols such as quercetin may exert several beneficial effects, including
those resulting from anti-inflammatory activities, but their impact on cardiovascular health is …
those resulting from anti-inflammatory activities, but their impact on cardiovascular health is …
Therapeutic roles of peroxisome proliferator–activated receptor agonists
B Staels, JC Fruchart - Diabetes, 2005 - Am Diabetes Assoc
Peroxisome proliferator–activated receptors (PPARs) play key roles in the regulation of
energy homeostasis and inflammation, and agonists of PPARα and-γ are currently used …
energy homeostasis and inflammation, and agonists of PPARα and-γ are currently used …
Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis
Background—Noninvasive imaging of adhesion molecules such as vascular cell adhesion
molecule-1 (VCAM-1) may identify early stages of inflammation in atherosclerosis. We …
molecule-1 (VCAM-1) may identify early stages of inflammation in atherosclerosis. We …
Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial
Results: L. reuteri NCIMB 30242 capsules reduced LDL-C by 11.64%(P< 0.001), total
cholesterol by 9.14%,(P< 0.001), non-HDL-cholesterol (non-HDL-C) by 11.30%(P< 0.001) …
cholesterol by 9.14%,(P< 0.001), non-HDL-cholesterol (non-HDL-C) by 11.30%(P< 0.001) …
Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation
S Kofler, T Nickel, M Weis - Clinical science, 2005 - portlandpress.com
Complex cellular and inflammatory interactions are involved in the progress of vascular
diseases. Endothelial cells, upon exposure to cytokines, undergo profound alterations of …
diseases. Endothelial cells, upon exposure to cytokines, undergo profound alterations of …
Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling …
M Di Napoli, M Schwaninger, R Cappelli, E Ceccarelli… - Stroke, 2005 - Am Heart Assoc
Background and Purpose—Several studies have shown, in different populations, that
modest elevation of plasma C-reactive protein (CRP) in the range seen in apparently …
modest elevation of plasma C-reactive protein (CRP) in the range seen in apparently …