Metastatic dissemination occurs very early in the malignant progression of a cancer but the
clinical manifestation of metastases often takes years. In recent decades, 5-year survival of …

Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in
host immune responses against infection and tumor growth. These cells have a powerful …

The metastatic spread of malignant cells to distant anatomical locations is a prominent
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …

Simple Summary Innate immune natural killer (NK) cells are capable of killing metastatic
cancer cells without activation by antigen-presenting cells beforehand. The cytotoxic effects …

Tumour cells migrate very early from primary sites to distant sites, and yet metastases often
take years to manifest themselves clinically or never even surface within a patient's lifetime …

Recent reports give insights into the role of the T-box transcription factors, T-bet and
Eomesodermin (Eomes), in NK cell biology. In this mini-review, we recapitulate the initial …

Innate lymphoid cells (ILCs) are a group of innate lymphocytes that do not express RAG-
dependent rearranged antigen-specific cell surface receptors. ILCs are classified into five …

Background Innate lymphoid cells (ILC) are part of a heterogeneous family of
haematopoietic effector cells which lack re-arranged antigen-specific receptors. They …

Natural killer (NK) cells are key innate immune effectors against multiple myeloma, their
activity declining in multiple myeloma patients with disease progression. To identify the …

Innate lymphoid cells (ILCs) consist of a heterogeneous family of lymphocytes that regulate
tissue homeostasis and can contribute to pathology in mice and humans. Mammalian group …