From structure to sequence: antibody discovery using cryoEM
One of the rate-limiting steps in analyzing immune responses to vaccines or infections is the
isolation and characterization of monoclonal antibodies. Here, we present a hybrid structural …
isolation and characterization of monoclonal antibodies. Here, we present a hybrid structural …
[HTML][HTML] New insights into pathogenesis point to HIV-1 Tat as a key vaccine target
B Ensoli, S Moretti, A Borsetti, MT Maggiorella… - Archives of …, 2021 - Springer
Despite over 30 years of enormous effort and progress in the field, no preventative and/or
therapeutic vaccines against human immunodeficiency virus (HIV) are available. Here, we …
therapeutic vaccines against human immunodeficiency virus (HIV) are available. Here, we …
Deep mining of human antibody repertoires: concepts, methodologies, and applications
X Tian, C Li, Y Wu, T Ying - Small Methods, 2020 - Wiley Online Library
The ability of the human adaptive immune system to respond to antigens relies upon the
tremendous diversity of T cell receptors (TCR) and B cell receptors (BCR). The entirety of an …
tremendous diversity of T cell receptors (TCR) and B cell receptors (BCR). The entirety of an …
Development of whole-porcine monoclonal antibodies with potent neutralization activity against classical swine fever virus from single B cells
H Dong, A Su, D Lv, L Ma, J Dong, N Guo… - ACS Synthetic …, 2019 - ACS Publications
Classical swine fever (CSF) is a highly contagious swine disease that causes devastating
economic losses. However, there are few efficacious therapeutic antibodies against the CSF …
economic losses. However, there are few efficacious therapeutic antibodies against the CSF …
Vaccine based on antibody-dependent cell-mediated cytotoxicity epitope on the H1N1 influenza virus increases mortality in vaccinated mice
J Wang, M Liu, N Ding, Y Li, J Shao, M Zhu… - Biochemical and …, 2018 - Elsevier
Antibody-dependent cell-mediated cytotoxicity bridges humoral immunity and cellular
immunity. Thus vaccine candidates which can elicit both broadly neutralizing antibodies and …
immunity. Thus vaccine candidates which can elicit both broadly neutralizing antibodies and …
[HTML][HTML] Identification of a HIV gp41-specific human monoclonal antibody with potent antibody-dependent cellular cytotoxicity
Z Yang, X Liu, Z Sun, J Li, W Tan, W Yu… - Frontiers in …, 2018 - frontiersin.org
Antibody-Dependent Cellular Cytotoxicity (ADCC) is a major mechanism of protection
against viral infections in vivo. Identification of HIV-1-specific monoclonal antibodies (mAbs) …
against viral infections in vivo. Identification of HIV-1-specific monoclonal antibodies (mAbs) …
[HTML][HTML] COVID-19 Vaccines and Public Anxiety: Antibody Tests May Be Widely Accepted
L Liu, X Wang, X Li, N Li - Frontiers in Public Health, 2022 - frontiersin.org
Background More than 200 countries are experiencing the coronavirus disease (COVID-19)
pandemic. COVID-19 vaccination strategies have been implemented worldwide, and repeat …
pandemic. COVID-19 vaccination strategies have been implemented worldwide, and repeat …
Magnetic Multiarm Scaffold for the One-Step Purification of Epitope-Specific Neutralizing Antibodies
D Lv, H Dong, A Su, Y Qin, J Dong, L Ma, J Li… - Analytical …, 2019 - ACS Publications
Epitope-specific neutralizing antibodies (EsAbs) are of prime importance in the diagnosis
and treatment of various serious diseases. However, obtaining EsAbs by the monoclonal …
and treatment of various serious diseases. However, obtaining EsAbs by the monoclonal …
[PDF][PDF] Defining the development of gp120-gp41 interface directed broadly neutralizing antibodies in HIV-1 infection
VN Hlatshwayo - 2023 - wiredspace.wits.ac.za
A prophylactic HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs)
against conserved HIV-1 envelope epitopes such as the gp120-gp41 interface which …
against conserved HIV-1 envelope epitopes such as the gp120-gp41 interface which …
From Structure to Sequence: Identification of polyclonal antibody families using cryoEM
One of the rate-limiting steps in analyzing immune responses to vaccines or infections is the
isolation and characterization of monoclonal antibodies. Here, we present a hybrid structural …
isolation and characterization of monoclonal antibodies. Here, we present a hybrid structural …