Pain is a major comorbidity of sickle cell disease (SCD). Patients with SCD may suffer from
both acute and chronic pain. Acute pain is caused by recurrent and unpredictable episodes …

Although descriptions of quality of life and patient reports of mood in sickle cell disease
(SCD) have become more common in the literature, less is known about psychiatric illness …

A deeper pathophysiologic understanding of available mouse models of sickle cell disease
(SCD), such as the Townes model, will help improve preclinical studies. We evaluated …

Sickle cell disease is a uniquely complex painful disease, with lifelong episodes of
unpredictable acute pain and superimposed chronic pain in adulthood. Both painful crises …

Pain has been recognized as the clinical hallmark of sickle cell disease (SCD) since its
initial description in the Western medical literature more than 100 years ago. Clinical and …

Sickle cell disease (SCD) is an autosomal recessive genetic disorder that affects∼ 100,000
Americans and millions of people worldwide. Erythrocyte sickling, vaso-occlusion, sterile …

Sickle cell disease (SCD) is a hemoglobinopathy affecting multiple organs and featuring
acute and chronic pain. Purkinje cell damage and hyperalgesia have been demonstrated in …

Introduction Opioids are used for acute and chronic pain in patients with sickle cell disease.
How outpatient opioid regimens relate to acute care visits is of interest given the risks of high …

Pain in Sickle Cell Disease (SCD) is a major comorbidity and unique with acute pain due to
recurrent and episodic vaso-occlusive crises as well as chronic pain, which can span an …

1 Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA, 2
Department of Pathology, Division of Transfusion Medicine and Hemostasis, The University …