Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative diseases

S Dabrowska, A Andrzejewska, M Janowski… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent stem cells derived from
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …

MSC based therapies—new perspectives for the injured lung

J Behnke, S Kremer, T Shahzad, CM Chao… - Journal of clinical …, 2020 - mdpi.com
Chronic lung diseases pose a tremendous global burden. At least one in four people suffer
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …

[HTML][HTML] AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages

L Xia, C Zhang, N Lv, Z Liang, T Ma, H Cheng, Y Xia… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Aberrant activation of macrophages with mitochondria dismiss was proved to be
associated with pathogenesis of ALI (acute lung injury). Exosomes from adipose-derived …

Microwave assisted antibacterial action of Garcinia nanoparticles on Gram-negative bacteria

Y Qiao, Y Xu, X Liu, Y Zheng, B Li, Y Han, Z Li… - Nature …, 2022 - nature.com
Owing to the existence of the outer membrane barrier, most antibacterial agents cannot
penetrate Gram-negative bacteria and are ineffective. Here, we report a general method for …

Preclinical efficacy and clinical safety of clinical‐grade nebulized allogenic adipose mesenchymal stromal cells‐derived extracellular vesicles

M Shi, Q Yang, A Monsel, J Yan, C Dai… - Journal of …, 2021 - Wiley Online Library
Mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EVs) turn out to be a
promising source of cell‐free therapy. Here, we investigated the biodistribution and effect of …

Mesenchymal stem cell‐based therapy of inflammatory lung diseases: current understanding and future perspectives

CR Harrell, R Sadikot, J Pascual… - Stem cells …, 2019 - Wiley Online Library
During acute or chronic lung injury, inappropriate immune response and/or aberrant repair
process causes irreversible damage in lung tissue and most usually results in the …

Biogenesis, composition and potential therapeutic applications of mesenchymal stem cells derived exosomes in various diseases

YG Yuan, JL Wang, YX Zhang, L Li… - International Journal …, 2023 - Taylor & Francis
Exosomes are nanovesicles with a wide range of chemical compositions used in many
different applications. Mesenchymal stem cell-derived exosomes (MSCs-EXOs) are …

Extracellular vesicles: novel communicators in lung diseases

A Mohan, S Agarwal, M Clauss, NS Britt… - Respiratory research, 2020 - Springer
The lung is the organ with the highest vascular density in the human body. It is therefore
perceivable that the endothelium of the lung contributes significantly to the circulation of …

Extracellular microvesicles as new industrial therapeutic frontiers

V Agrahari, V Agrahari, PA Burnouf, CH Chew… - Trends in …, 2019 - cell.com
Microvesicles (MVs) are subcellular physiological vehicles present in all body fluids that
mediate the transfer of intercellular information within biological systems and contribute to …

Mesenchymal stem cell-macrophage crosstalk and maintenance of inflammatory microenvironment homeostasis

D Lu, Y Xu, Q Liu, Q Zhang - Frontiers in cell and developmental …, 2021 - frontiersin.org
Macrophages are involved in almost every aspect of biological systems and include
development, homeostasis and repair. Mesenchymal stem cells (MSCs) have good clinical …