Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Similar to neurodegenerative diseases, the concept that tumors are prion like diseases has
been proposed in recent years. p53, the most well-known tumor suppressor, has been …

Liquid–liquid Phase Separation (LLPS) of proteins and nucleic acids has emerged as a new
paradigm in the study of cellular activities. It drives the formation of liquid-like condensates …

Mutant p53 tends to form aggregates with amyloid properties, especially amyloid oligomers
inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The …

Simple Summary The well-known tumor suppressor protein p53 plays important roles in
tumor prevention through transcriptional regulation of its target genes. Reactivation of p53 …

The p53 family of proteins evolved from a common ancestor into three separate genes
encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each …

Ancillary immunohistochemistry (IHC) has become a reliable adjunct for subclassification of
gynecological neoplasms. An important recent development was optimization and validation …

ABSTRACT p53 (also known as TP53) mutation and amyloid formation are long associated
with cancer pathogenesis; however, the direct demonstration of the link between p53 …

The global transcription factor, p53, is a master regulator of gene expression in cells.
Mutations in the TP53 gene promote unregulated cell growth through the inactivation of …

Our previous studies have shown that p53 isoform expression is altered in breast cancer
and related to prognosis. In particular, a high∆ 40p53: p53α ratio is associated with worse …