How changes in dopamine D2 receptor levels alter striatal circuit function and motivation

EH Simpson, EF Gallo, PD Balsam, JA Javitch… - Molecular …, 2022 - nature.com
It was first posited, more than five decades ago, that the etiology of schizophrenia involves
overstimulation of dopamine receptors. Since then, advanced clinical research methods …

GPCR-based dopamine sensors—a detailed guide to inform sensor choice for in vivo imaging

MA Labouesse, RB Cola, T Patriarchi - International journal of molecular …, 2020 - mdpi.com
Understanding how dopamine (DA) encodes behavior depends on technologies that can
reliably monitor DA release in freely-behaving animals. Recently, red and green genetically …

Maternal low-dose aspartame and stevia consumption with an obesogenic diet alters metabolism, gut microbiota and mesolimbic reward system in rat dams and their …

JE Nettleton, NA Cho, T Klancic, AC Nicolucci… - Gut, 2020 - gut.bmj.com
Objective We examined the impact of maternal low-dose aspartame and stevia consumption
on adiposity, glucose tolerance, gut microbiota and mesolimbic pathway in obese dams and …

A high-fat high-sugar diet in adolescent rats impairs social memory and alters chemical markers characteristic of atypical neuroplasticity and parvalbumin interneuron …

AC Reichelt, GD Gibson, KN Abbott, DJ Hare - Food & function, 2019 - pubs.rsc.org
Brain plasticity is a multifaceted process that is dependent on both neurons and extracellular
matrix (ECM) structures, including perineuronal nets (PNNs). In the medial prefrontal cortex …

Deep brain stimulation for obesity: a review and future directions

DA Formolo, JM Gaspar, HM Melo, T Eichwald… - Frontiers in …, 2019 - frontiersin.org
The global prevalence of obesity has been steadily increasing. Although pharmacotherapy
and bariatric surgeries can be useful adjuvants in the treatment of morbid obesity, they may …

Hypothalamic dopamine signalling regulates brown fat thermogenesis

C Folgueira, D Beiroa, B Porteiro, M Duquenne… - Nature …, 2019 - nature.com
Dopamine signalling is a crucial part of the brain reward system and can affect feeding
behaviour. Dopamine receptors are also expressed in the hypothalamus, which is known to …

Modified in situ Hybridization Chain Reaction Using Short Hairpin DNAs

Y Tsuneoka, H Funato - Frontiers in Molecular Neuroscience, 2020 - frontiersin.org
The visualization of multiple gene expressions in well-preserved tissues is crucial for the
elucidation of physiological and pathological processes. In situ hybridization chain reaction …

Fluorescence quenching by high-power LEDs for highly sensitive fluorescence in situ hybridization

Y Tsuneoka, Y Atsumi, A Makanae… - Frontiers in molecular …, 2022 - frontiersin.org
Recent technical advances have made fluorescent in situ hybridization (ISH) a pivotal
method to analyze neural tissue. In a highly sensitive ISH, it is important to reduce tissue …

Role of the striatal dopamine, GABA and opioid systems in mediating feeding and fat intake

A Joshi, M Schott, SE La Fleur, M Barrot - Neuroscience & Biobehavioral …, 2022 - Elsevier
Food intake, which is a highly reinforcing behavior, provides nutrients required for survival in
all animals. However, when fat and sugar consumption goes beyond the daily needs, it can …

Dietary lipids as regulators of reward processes: multimodal integration matters

C Berland, DM Small, S Luquet… - Trends in Endocrinology & …, 2021 - cell.com
The abundance of energy-dense and palatable diets in the modern food environment tightly
contributes to the obesity pandemic. The reward circuit participates to the regulation of body …