Visualization of the cellular heterogeneity and spatial architecture of the tumor
microenvironment (TME) is becoming increasingly important to understand mechanisms of …

Cellular senescence is a critical stress response program implicated in embryonic
development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate …

Tissues are organized in cellular niches, the composition and interactions of which can be
investigated using spatial omics technologies. However, systematic analyses of tissue …

Understanding the role of the tumor microenvironment (TME) in lung cancer is critical to
improving patient outcomes. We identified four histology-independent archetype TMEs in …

Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

In recent years, the application of advanced analytics, especially artificial intelligence (AI), to
digital H&E images, and other histological image types, has begun to radically change how …

Myeloid immune cells (MICs) are potent innate immune cells serving as first responders to
invading pathogens and internal changes to cellular homeostasis. Cancer is a stage of …

Cells can rapidly adjust their proteomes in dynamic environments by regulating mRNA
translation. There is mounting evidence that dysregulation of mRNA translation supports the …

Highlights•Tissue-resident macrophages are a potent source of TAMs.•TRM–TAMs exhibit
diverse functional properties across different cancers.•Tissue context and spatial territories …

Allograft rejection is common following clinical organ transplantation, but defining specific
immune subsets mediating alloimmunity has been elusive. Calcineurin inhibitor dose …