On the basis of its generally accessible I/II redox couple and bioavailability, copper plays a
wide variety of roles in nature that mostly involve electron transfer (ET), O 2 binding …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Electrons can tunnel through proteins in microseconds with a modest release of free energy
over distances in the 15 to 20 Å range. To span greater distances, or to move faster, multiple …

Copper (Cu) is an essential micronutrient for most organisms and serves mainly as a redox-
active catalytic centre in enzymes cycling between Cu+ and Cu 2+. Membrane transporters …

The chemical properties of copper allow it to take part in many biological functions such as
electron transfer, catalysis, and structural shaping. The ability to cycle between+ 1 and+ 2 …

Factor VIII (fVIII) is a serum protein in the coagulation cascade that nucleates the assembly
of a membrane-bound protease complex on the surface of activated platelets at the site of a …

Aceruloplasminemia (ACP) is a rare, adult-onset, autosomal recessive disorder,
characterized by systemic iron overload due to mutations in the Ceruloplasmin gene (CP) …

The mammalian multicopper ferroxidases (MCFs) ceruloplasmin (CP), hephaestin (HEPH)
and zyklopen (ZP) comprise a family of conserved enzymes that are essential for body iron …

There are two barriers for iron entry into the brain:(1) the brain–cerebrospinal fluid (CSF)
barrier and (2) the blood–brain barrier (BBB). Here, we review the literature on …

The fraction of copper not bound to ceruloplasmin seems altered in Alzheimer's disease
(AD). We have addressed this notion evaluating all the studies carried out from 1996 until …