With the increasing application of medical imaging contrast materials, contrast-induced
nephropathy has become one of the leading causes of iatrogenic renal insufficiency. The …

The cellular mechanisms and signaling network that guide the cardiac disease
pathophysiology are inextricably intertwined, which explains the current scarcity of effective …

Aims Acute kidney injury (AKI) can limit the clinical use of cisplatin in cancer treatment. The
drivers of cisplatin-induced AKI include oxidative stress, mitochondrial dysfunction and …

The gene SerpinC1 encodes a serine protease inhibitor named antithrombin III (ATIII). This
protease demonstrates both anticoagulant and anti-inflammatory action. ATIII is the most …

Renalase was discovered as a protein synthesized by the kidney and secreted in blood
where it circulates at a concentration of approximately 3–5 μg/ml. Initial reports suggested …

Diabetes mellitus is an independent risk factor for renal impairment in patients exposed to
contrast media. It doubles the risk and decreases survival rate of contrast induced …

Objective: The systemic immune-inflammation index (SII), derived from counts of neutrophils,
platelets, and lymphocytes, has been developed to predict clinical outcomes in several …

Oxidative stress and inflammation have been demonstrated to be involved in the onset and
promotion of diabetic nephropathy (DN). Tanshinone IIA (Tan) possesses both antioxidant …

We previously reported that insufficiency of antithrombin III (ATIII), the major anti-coagulation
molecule in vivo, exacerbated renal ischemia-reperfusion injury in animal models and …

The survival factor renalase (RNLS) is a recently discovered secretory protein with potent
prosurvival and anti-inflammatory effects. Several evolutionarily conserved RNLS domains …