[HTML][HTML] Computational analyses of mechanism of action (MoA): data, methods and integration
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the
drug discovery process, but it is important in order to rationalise phenotypic findings and to …
drug discovery process, but it is important in order to rationalise phenotypic findings and to …
[HTML][HTML] Building a knowledge graph to enable precision medicine
Developing personalized diagnostic strategies and targeted treatments requires a deep
understanding of disease biology and the ability to dissect the relationship between …
understanding of disease biology and the ability to dissect the relationship between …
[HTML][HTML] Computer vision and IoT research landscape for health and safety management on construction sites
Aims Perform a systematic review of current literature to evaluate and summarise the health
and safety hazards on construction sites. Methods Science Direct, SCOPUS and web of …
and safety hazards on construction sites. Methods Science Direct, SCOPUS and web of …
[HTML][HTML] AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination
Artificial intelligence-based protein structure prediction methods such as AlphaFold have
revolutionized structural biology. The accuracies of these predictions vary, however, and …
revolutionized structural biology. The accuracies of these predictions vary, however, and …
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19
MGP van der Wijst, SE Vazquez… - Science translational …, 2021 - science.org
Neutralizing autoantibodies against type I interferons (IFNs) have been found in some
patients with critical coronavirus disease 2019 (COVID-19), the disease caused by severe …
patients with critical coronavirus disease 2019 (COVID-19), the disease caused by severe …
An in vitro model of early anteroposterior organization during human development
The body plan of the mammalian embryo is shaped through the process of gastrulation, an
early developmental event that transforms an isotropic group of cells into an ensemble of …
early developmental event that transforms an isotropic group of cells into an ensemble of …
[HTML][HTML] An activity-guided map of electrophile-cysteine interactions in primary human T cells
Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …
on immune cells. These compounds are thought to act by cysteine modification to alter the …
[HTML][HTML] Generative modeling of brain maps with spatial autocorrelation
Studies of large-scale brain organization have revealed interesting relationships between
spatial gradients in brain maps across multiple modalities. Evaluating the significance of …
spatial gradients in brain maps across multiple modalities. Evaluating the significance of …
[HTML][HTML] Defining the condensate landscape of fusion oncoproteins
Fusion oncoproteins (FOs) arise from chromosomal translocations in~ 17% of cancers and
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …
[HTML][HTML] Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells
S Funakoshi, I Fernandes, O Mastikhina… - Nature …, 2021 - nature.com
Compact cardiomyocytes that make up the ventricular wall of the adult heart represent an
important therapeutic target population for modeling and treating cardiovascular diseases …
important therapeutic target population for modeling and treating cardiovascular diseases …