Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and
resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past …

Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease
characterized by insulin deficiency due to pancreatic β-cell loss and leads to …

The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of
digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone …

Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …

Chronic exposure of glucose rich environment creates several physiological and
pathophysiological changes. There are several pathways by which hyperglycemia …

Impaired function of pancreatic islet cells is a major cause of metabolic dysregulation and
disease in humans. Despite this, it remains challenging to directly link physiological …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes
has grown substantially, particularly with regard to disease prediction and heterogeneity …

Despite major advances over the past decade, prevention and treatment of type 1 diabetes
mellitus (T1DM) remain suboptimal, with large and unexplained variations in individual …