From nanoparticles to cancer nanomedicine: old problems with new solutions
Anticancer nanomedicines have been studied over 30 years, but fewer than 10 formulations
have been approved for clinical therapy today. Despite abundant options of anticancer …
have been approved for clinical therapy today. Despite abundant options of anticancer …
PEI functionalized cell membrane for tumor targeted and glutathione responsive gene delivery
M Wang, H Huang, Y Sun, M Wang, Z Yang… - International Journal of …, 2024 - Elsevier
Polyethylenimine (PEI) is a broadly exploited cationic polymer due to its remarkable gene-
loading capacity. However, the high cytotoxicity caused by its high surface charge density …
loading capacity. However, the high cytotoxicity caused by its high surface charge density …
EphA2-Receptor Targeted PEGylated Nanoliposomes for the Treatment of BRAFV600E Mutated Parent- and Vemurafenib-Resistant Melanoma
The clinical outcomes of malignant melanoma have improved with the introduction of
mitogen-activated protein kinase kinase (MEK) inhibitors. However, off-target toxicities of the …
mitogen-activated protein kinase kinase (MEK) inhibitors. However, off-target toxicities of the …
Liposomal aerosols of nitric oxide (NO) donor as a long-acting substitute for the ultra-short-acting inhaled NO in the treatment of PAH
Purpose This study seeks to develop a liposomal formulation of diethylenetriamine
NONOate (DN), a long acting nitric oxide (NO) donor, with a goal to replace inhaled NO …
NONOate (DN), a long acting nitric oxide (NO) donor, with a goal to replace inhaled NO …
Synthesis of polymer-lipid nanoparticles by microfluidic focusing for siRNA delivery
Y Li, X Huang, RJ Lee, Y Qi, K Wang, F Hao, Y Zhang… - Molecules, 2016 - mdpi.com
Polyethylenimine (PEI) as a cationic polymer is commonly used as a carrier for gene
delivery. PEI-800 is less toxic than PEI-25K but it is also less efficient. A novel nanocarrier …
delivery. PEI-800 is less toxic than PEI-25K but it is also less efficient. A novel nanocarrier …
Investigation of PLGA nanoparticles in conjunction with nuclear localization sequence for enhanced delivery of antimiR phosphorothioates in cancer cells in vitro
S Malik, R Bahal - Journal of nanobiotechnology, 2019 - Springer
Numerous first generation phosphorothioates (PS) and their derivatives have shown
promise targeting mRNA for therapeutic applications and also gained market approval for …
promise targeting mRNA for therapeutic applications and also gained market approval for …
Enhancing the safety and effectiveness of polyethylenimine gene delivery through cell membrane encapsulation
M Wang, Y Sun, M Wang, Z Yang, Y Shi, D Zeng… - Journal of Drug Delivery …, 2024 - Elsevier
Due to the powerful DNA loading capacity and excellent proton sponge effect, the cationic
polymer polyethyleneimine (PEI) has been demonstrated as a versatile, efficient DNA …
polymer polyethyleneimine (PEI) has been demonstrated as a versatile, efficient DNA …
[HTML][HTML] STAT3-siRNA induced B16. F10 melanoma cell death: more association with VEGF downregulation than p-STAT3 knockdown
A Alshamsan - Saudi pharmaceutical journal, 2018 - Elsevier
STAT3 knockdown by small interfering RNA (siRNA) has been described to inhibit
carcinogenic growth in various types of tumors. Earlier we have reported delivery of siRNA …
carcinogenic growth in various types of tumors. Earlier we have reported delivery of siRNA …