Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …

FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a
variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA …

Berberine is a plant metabolite belonging to the group of isoquinoline alkaloids with strong
biological and pharmacological activity. Currently, berberine is receiving considerable …

Figure 2. Regulation of the Rho GTPase cycle. Rho protein cycle between an inactive GDP-
bound and an active GTP-bound state. Inhibition of the mevalonate synthesis by statins …

Statins are 3-hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase inhibitors, which
are prescribed extensively for cholesterol lowering in the primary and secondary prevention …

Baicalein is a natural flavonoid extracted from the root of Scutellaria baicalensis that exhibits
a variety of pharmacological activities. In this study, we investigated the molecular …

One of the greatest examples of integrated signal transduction is revealed by examination of
effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of …

Left ventricular non-compaction (LVNC) is the third most prevalent cardiomyopathy in
children and its pathogenesis has been associated with the developmental defect of the …

Sarcopenia due to loss of skeletal muscle mass and strength leads to physical inactivity and
decreased quality of life. The number of individuals with sarcopenia is rapidly increasing as …

Abstract The Forkhead box O (FoxO) family has recently been highlighted as an important
transcriptional regulator of crucial proteins associated with the many diverse functions of …