Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …

Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

Cardiac remodeling is typically associated with disease and can lead to heart failure. In
contrast, remodeling that occurs in the athlete's heart is considered an adaptive …

Declining mobility is a major concern, as well as a major source of health care costs, among
the elderly population. Lack of mobility is a primary cause of entry into managed care …

Aims Regulated necrosis (necroptosis) and apoptosis are important biological features of
myocardial infarction, ischaemia-reperfusion (I/R) injury, and heart failure. However, the …

Recent evidences have shown that exercise training not only plays a necessary role in
maintaining cardiac homeostasis, but also promotes cardiac repair after myocardial …

Phosphatidylinositol 3-kinases (PI3Ks) are key molecules in the signal transduction
pathways initiated by the binding of extracellular signals to their cell surface receptors. The …

Ageing in humans is associated with a significant increase in the prevalence of
cardiovascular disease. We still do not fully understand the molecular mechanisms …

Cardiac hypertrophy is an adaptive response to haemodynamic stress. Pressure and/or
volume overload in hypertension, myocardial infarction (MI) and valvular heart disease are …

The heart is continuously faced with a dynamic workload and is able to respond by
modifying its size and shape. In response to acute hemodynamic loads (eg short term …