[HTML][HTML] Strategies to prolong the residence time of drug delivery systems on ocular surface
Ocular diseases may be treated via different routes of administration, such as topical,
intracameral, intravitreal, oral and parenteral. Among them the topical route is most accepted …
intracameral, intravitreal, oral and parenteral. Among them the topical route is most accepted …
Cellulosic polymers for enhancing drug bioavailability in ocular drug delivery systems
One of the major impediments to drug development is low aqueous solubility and thus poor
bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the …
bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the …
Mucoadhesive dexamethasone-glycol chitosan nanoparticles for ophthalmic drug delivery
A Yu, H Shi, H Liu, Z Bao, M Dai, D Lin, D Lin… - International Journal of …, 2020 - Elsevier
Self-assembly of drug-polysacrrides conjugates forming nanostructures provides a simple
and promising strategy for the extension of precorneal retention and enhancement of …
and promising strategy for the extension of precorneal retention and enhancement of …
[HTML][HTML] Lipid based formulations as supersaturating oral delivery systems: from current to future industrial applications
Lipid-based formulations, in particular supersaturated lipid-based formulations, are
important delivery approaches when formulating challenging compounds, as especially low …
important delivery approaches when formulating challenging compounds, as especially low …
[HTML][HTML] Non-aqueous formulations in topical ocular drug delivery–A paradigm shift?
P Agarwal, ID Rupenthal - Advanced Drug Delivery Reviews, 2023 - Elsevier
Topical eyedrop application is the preferred route for drug delivery to anterior segment
tissues; however, the challenge of overcoming the eye's anatomical and physiological …
tissues; however, the challenge of overcoming the eye's anatomical and physiological …
Improved oral bioavailability of capsaicin via liposomal nanoformulation: preparation, in vitro drug release and pharmacokinetics in rats
Y Zhu, M Wang, J Zhang, W Peng… - Archives of pharmacal …, 2015 - Springer
This study innovatively prepared an effective capsaicin-loaded liposome, a nanoformulation
with fewer irritants, for oral administration. The in vitro and in vivo properties of the liposomal …
with fewer irritants, for oral administration. The in vitro and in vivo properties of the liposomal …
[HTML][HTML] Optimal design of novel microemulsions-based two-layered dissolving microneedles for delivering fluconazole in treatment of fungal eye infection
P Suriyaamporn, P Opanasopit, W Rangsimawong… - Pharmaceutics, 2022 - mdpi.com
The optimal design of novel microneedles (MNs) for the ocular delivery system is necessary
and useful for improving the effectiveness of medication. The objective of this study was to …
and useful for improving the effectiveness of medication. The objective of this study was to …
Enhanced intestinal permeability of cefixime by self-emulsifying drug delivery system: in-vitro and ex-vivo characterization
Background: Cefixime (CFX) belongs to a group of third-generation cephalosporin
antibiotics with low water solubility and low intestinal permeability, which ultimately leads to …
antibiotics with low water solubility and low intestinal permeability, which ultimately leads to …
Etoricoxib-loaded bio-adhesive hybridized polylactic acid-based nanoparticles as an intra-articular injection for the treatment of osteoarthritis
Osteoarthritis is a major problem in elder people. Etoricoxib-loaded bio-adhesive hybridized
nanoparticles were prepared using polylactic acid (PLA) and chitosan hydrochloride (CS …
nanoparticles were prepared using polylactic acid (PLA) and chitosan hydrochloride (CS …
Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation
Y Zhu, W Peng, J Zhang, M Wang… - Journal of Functional …, 2014 - Elsevier
The aim of this study was to prepare capsaicin-loaded micelle for oral administration and
pharmacokinetic studies in rats. The formulated capsaicin consisted of polyvinylpyrrolidone …
pharmacokinetic studies in rats. The formulated capsaicin consisted of polyvinylpyrrolidone …