Ocular diseases may be treated via different routes of administration, such as topical,
intracameral, intravitreal, oral and parenteral. Among them the topical route is most accepted …

One of the major impediments to drug development is low aqueous solubility and thus poor
bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the …

Self-assembly of drug-polysacrrides conjugates forming nanostructures provides a simple
and promising strategy for the extension of precorneal retention and enhancement of …

Lipid-based formulations, in particular supersaturated lipid-based formulations, are
important delivery approaches when formulating challenging compounds, as especially low …

Topical eyedrop application is the preferred route for drug delivery to anterior segment
tissues; however, the challenge of overcoming the eye's anatomical and physiological …

This study innovatively prepared an effective capsaicin-loaded liposome, a nanoformulation
with fewer irritants, for oral administration. The in vitro and in vivo properties of the liposomal …

The optimal design of novel microneedles (MNs) for the ocular delivery system is necessary
and useful for improving the effectiveness of medication. The objective of this study was to …

Background: Cefixime (CFX) belongs to a group of third-generation cephalosporin
antibiotics with low water solubility and low intestinal permeability, which ultimately leads to …

Osteoarthritis is a major problem in elder people. Etoricoxib-loaded bio-adhesive hybridized
nanoparticles were prepared using polylactic acid (PLA) and chitosan hydrochloride (CS …

The aim of this study was to prepare capsaicin-loaded micelle for oral administration and
pharmacokinetic studies in rats. The formulated capsaicin consisted of polyvinylpyrrolidone …