Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future

Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Emerging roles of innate and adaptive immunity in Alzheimer's disease

X Chen, DM Holtzman - Immunity, 2022 - cell.com
Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …

[HTML][HTML] Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease

JS Sadick, MR O'Dea, P Hasel, T Dykstra, A Faustin… - Neuron, 2022 - cell.com
Resolving glial contributions to Alzheimer's disease (AD) is necessary because changes in
neuronal function, such as reduced synaptic density, altered electrophysiological properties …

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

F Leng, P Edison - Nature Reviews Neurology, 2021 - nature.com
Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer's disease

D Singh - Journal of neuroinflammation, 2022 - Springer
Neuroinflammation is instigated by the misfiring of immune cells in the central nervous
system (CNS) involving microglia and astrocytes as key cell-types. Neuroinflammation is a …

Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease

CC Liu, N Wang, Y Chen, Y Inoue, F Shue, Y Ren… - Nature …, 2023 - nature.com
Microglial involvement in Alzheimer's disease (AD) pathology has emerged as a risk-
determining pathogenic event. While apolipoprotein E (APOE) is known to modify AD risk, it …

[HTML][HTML] Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

A Więckowska-Gacek, A Mietelska-Porowska… - Ageing research …, 2021 - Elsevier
An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling

J Xie, L Cools, G Van Imschoot… - Journal of …, 2023 - Wiley Online Library
The gut microbiota represents a diverse and dynamic population of microorganisms that can
influence the health of the host. Increasing evidence supports the role of the gut microbiota …

Interaction of microglia and astrocytes in the neurovascular unit

L Liu, J Liu, J Bao, Q Bai, G Wang - Frontiers in immunology, 2020 - frontiersin.org
The interaction between microglia and astrocytes significantly influences neuroinflammation.
Microglia/astrocytes, part of the neurovascular unit (NVU), are activated by various brain …

Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response

S Bachiller, I Jiménez-Ferrer, A Paulus… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …