Lysophospholipid receptors: signaling and biology
▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling
CE Chalfant, S Spiegel - Journal of cell science, 2005 - journals.biologists.com
The phosphorylated sphingolipid metabolites sphingosine 1-phosphate (S1P) and ceramide
1-phosphate (C1P) have emerged as potent bioactive agents. Recent studies have begun to …
1-phosphate (C1P) have emerged as potent bioactive agents. Recent studies have begun to …
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency
Steroid-resistant nephrotic syndrome (SRNS) causes 15% of chronic kidney disease cases.
A mutation in 1 of over 40 monogenic genes can be detected in approximately 30% of …
A mutation in 1 of over 40 monogenic genes can be detected in approximately 30% of …
A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals
RA Alegado, LW Brown, S Cao, RK Dermenjian… - elife, 2012 - elifesciences.org
Bacterially-produced small molecules exert profound influences on animal health,
morphogenesis, and evolution through poorly understood mechanisms. In one of the closest …
morphogenesis, and evolution through poorly understood mechanisms. In one of the closest …
[HTML][HTML] Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism
DM Zu Heringdorf, KH Jakobs - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA),
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
Effects of diet and development on the Drosophila lipidome
Cells produce tens of thousands of different lipid species, but the importance of this
complexity in vivo is unclear. Analysis of individual tissues and cell types has revealed …
complexity in vivo is unclear. Analysis of individual tissues and cell types has revealed …
Point-counterpoint of sphingosine 1-phosphate metabolism
Sphingosine 1-phosphate (S1P), an evolutionarily conserved bioactive lipid mediator, is
now recognized as a potent modulator of cell regulation. In vertebrates, S1P interacts with …
now recognized as a potent modulator of cell regulation. In vertebrates, S1P interacts with …
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function
Sphingosine 1-phosphate (S1P) is a polar sphingolipid metabolite that regulates cell
migration, differentiation, survival and complex physiological processes (Bartke and …
migration, differentiation, survival and complex physiological processes (Bartke and …
Sphingolipids in neurodegenerative diseases
Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive
deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is …
deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is …
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation
M Kohno, M Momoi, ML Oo, JH Paik… - … and cellular biology, 2006 - Am Soc Microbiol
Sphingosine kinase (Sphk) enzymes are important in intracellular sphingolipid metabolism
as well as in the biosynthesis of sphingosine 1-phosphate (S1P), an extracellular lipid …
as well as in the biosynthesis of sphingosine 1-phosphate (S1P), an extracellular lipid …