Many natural substances are efficient in vitro and in vivo for the treatment of various
disorders. However, treatment is often limited by their low bioavailability, water solubility and …

Poorly water soluble drugs tend to have low bioavailability, however, this can be improved
by several methods. One of the most promising strategies is the employment of solid …

Ocular drug delivery provides a challenging opportunity to develop optimal formulations with
proper therapeutic effects and acceptable patient compliance because there are many …

A modified method for ibuprofen/β-cyclodextrin (IBU/β-CD) complex formation, based on ball
milling (BM) under controlled conditions was developed and its efficiency with respect to the …

Nanoparticle engineering is a well-defined technique employed as a novel and effective
method in drug design and delivery. It is widely used to control particle size, as well as the …

The aim of the present study was to increase the solubility of an anti-allergic drug loratadine
by making its inclusion complex with β-cyclodextrin and to develop it's thermally triggered …

The formation steps of inclusion complex caused by co-grinding loratadine (LOR) and
hydroxypropyl-β-cyclodextrin (HP-β-CD) with a molar ratio of 1: 1 or 1: 2 were quantitatively …

Loratadine is a class II water-insoluble drug and its dissolution rate and, consequently,
absorption are dependent on the gastrointestinal pH. The resulting very high variability in …

This study investigates the effects of drug-loaded nanofibers on the solubility of the poorly
water-soluble drug, loratadine. Amorphous morphologies of electrospun loratadine …

Purpose: Loratadine is used as antihistaminic without side effects in nervous systems. This
drug is a weak base and it is absorbed from the intestine. The nitrogen of the pyridine ring is …