The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes
JA Pearson, FS Wong, L Wen - Journal of autoimmunity, 2016 - Elsevier
Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …
Humanized mice in translational biomedical research
LD Shultz, F Ishikawa, DL Greiner - Nature Reviews Immunology, 2007 - nature.com
The culmination of decades of research on humanized mice is leading to advances in our
understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity …
understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity …
Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγnull humanized mice
LD Shultz, Y Saito, Y Najima… - Proceedings of the …, 2010 - National Acad Sciences
Whereas humanized mouse models have contributed significantly to human immunology
research, human T cells developing in mouse thymic environment fail to demonstrate HLA …
research, human T cells developing in mouse thymic environment fail to demonstrate HLA …
Antigen targets of type 1 diabetes autoimmunity
Type 1 diabetes is characterized by recognition of one or more β-cell proteins by the
immune system. The list of target antigens in this disease is ever increasing and it is …
immune system. The list of target antigens in this disease is ever increasing and it is …
The role of NOD mice in type 1 diabetes research: lessons from the past and recommendations for the future
For more than 35 years, the NOD mouse has been the primary animal model for studying
autoimmune diabetes. During this time, striking similarities to the human disease have been …
autoimmune diabetes. During this time, striking similarities to the human disease have been …
Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes
TP Di Lorenzo, M Peakman… - Clinical & Experimental …, 2007 - academic.oup.com
T cell epitopes represent the molecular code words through which the adaptive immune
system communicates. In the context of a T cell-mediated autoimmune disease such as type …
system communicates. In the context of a T cell-mediated autoimmune disease such as type …
Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers
JH Velthuis, WW Unger, JRF Abreu, G Duinkerken… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Type 1 diabetes results from selective T-cell–mediated destruction of the insulin-
producing β-cells in the pancreas. In this process, islet epitope–specific CD8+ T-cells play a …
producing β-cells in the pancreas. In this process, islet epitope–specific CD8+ T-cells play a …
Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease
For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model
for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type …
for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type …
CD8+ T-Cell Responses Identify β-Cell Autoimmunity in Human Type 1 Diabetes
Despite the understanding that type 1 diabetes pathogenesis is mediated by T-cells,
detection of these rare lymphocytes remains largely elusive. Suitable T-cell assays are …
detection of these rare lymphocytes remains largely elusive. Suitable T-cell assays are …
CD8+ T cells in type 1 diabetes
Abstract Type 1 diabetes (T1D), an autoimmune disease once thought to be mediated
exclusively by β cell-specific CD4+ T cells, is now recognized as one in which autoreactive …
exclusively by β cell-specific CD4+ T cells, is now recognized as one in which autoreactive …