Accurate and reliable intraoperative neuronavigation is crucial for achieving maximal safe
resection of brain tumors. Intraoperative MRI (iMRI) has received significant attention as the …

5-Aminolevulinic acid (5-ALA) is the key precursor for the biosynthesis of tetrapyrrole
compounds, with wide applications in medicine, agriculture and other burgeoning fields …

Glioblastoma multiforme (GBM) represents the most common and aggressive central
nervous system tumor associated with a poor prognosis. The aim of this study was to depict …

Importance High-grade gliomas (HGG) are the most aggressive and common malignant
brain tumors in adults. They have a dismally fatal prognosis. Even if gross total resection of …

Intraoperative ultrasound (IOUS) is becoming progressively more common during brain
tumor surgery. We present data from our case series of brain tumor surgery performed with …

Purpose The extent of resection (EOR) is an independent prognostic factor for overall
survival (OS) in adult patients with Glioma Grade 4 (GG4). The aim of the neuro-oncology …

Safely maximizing extent of resection has become the central goal in glioma surgery.
Especially in eloquent cortex, the goal of maximal resection is balanced with neurological …

In the case of resection of gliomas involving eloquent areas, equal consideration should be
given to maintain maximal extent of resection (EOR) and neurological protection, for which …

Predictive factors for response to regorafenib in recurrent glioblastoma, IDH-wildtype, are
scarcely recognized. The objective of this study was to identify molecular predictive factors …

Background Surgical management of gliomas is predicated on “safe maximal resection”
across all histopathologic grades because progression-free survival and overall survival are …