Multiple factors combined are currently recognized as contributors to cognitive decline. The
main independent risk factor for cognitive impairment and dementia is advanced age …

Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

Multiple factors affect cognitive health, such as age-related changes in the brain, injuries,
mood disorders, substance abuse, and diseases. While some cannot be changed, evidence …

The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

Major New York Times bestseller Winner of the National Academy of Sciences Best Book
Award in 2012 Selected by the New York Times Book Review as one of the ten best books …

Dementia is caused by factors that damage neurons. We quantified small molecular markers
in whole blood of dementia patients, using nontargeted liquid chromatography–mass …

OBJECTIVE: Coffee is a beverage used worldwide. It includes a wide array of components
that can have potential implication on health. We have reviewed publications on the impact …

Caffeine, a xanthine alkaloid compound, is consumed widely and daily by humans, as it is
present in several regular beverages such as tea, coffee, soda beverages, and some drugs …

Synaptic plasticity in the autoassociative network of recurrent connections among
hippocampal CA3 pyramidal cells is thought to enable the storage of episodic memory …

Over the last decade, Food Regulation Authorities have concluded that coffee/caffeine
consumption is not harmful if consumed at levels of 200 mg in one sitting (around 2½ cups of …