Emerging nanomedicine approaches fighting tumor metastasis: animal models, metastasis-targeted drug delivery, phototherapy, and immunotherapy
Metastasis is directly or indirectly responsible for the majority of cancer deaths. Anti-
metastasis treatment is thus the key to cure cancer. Recent development in nanomedicine …
metastasis treatment is thus the key to cure cancer. Recent development in nanomedicine …
[HTML][HTML] Improving radiotherapy in cancer treatment: Promises and challenges
HHW Chen, MT Kuo - Oncotarget, 2017 - ncbi.nlm.nih.gov
Effective radiotherapy for cancer has relied on the promise of maximally eradicating tumor
cells while minimally killing normal cells. Technological advancement has provided state-of …
cells while minimally killing normal cells. Technological advancement has provided state-of …
Cancer stemness, intratumoral heterogeneity, and immune response across cancers
Regulatory programs that control the function of stem cells are active in cancer and confer
properties that promote progression and therapy resistance. However, the impact of a stem …
properties that promote progression and therapy resistance. However, the impact of a stem …
[HTML][HTML] The role of epithelial-to-mesenchymal plasticity in ovarian cancer progression and therapy resistance
Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading
cause of cancer-related deaths among women worldwide. The main reasons for this poor …
cause of cancer-related deaths among women worldwide. The main reasons for this poor …
[HTML][HTML] Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population
Although inactivation of the PTEN gene has been implicated in the development of
resistance to the HER2 targeting antibody trastuzumab, the mechanisms mediating this …
resistance to the HER2 targeting antibody trastuzumab, the mechanisms mediating this …
Salinomycin as a drug for targeting human cancer stem cells
C Naujokat, R Steinhart - BioMed Research International, 2012 - Wiley Online Library
Cancer stem cells (CSCs) represent a subpopulation of tumor cells that possess self‐
renewal and tumor initiation capacity and the ability to give rise to the heterogenous …
renewal and tumor initiation capacity and the ability to give rise to the heterogenous …
Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells
AK Srivastava, C Han, R Zhao, T Cui… - Proceedings of the …, 2015 - National Acad Sciences
Cancer stem cells (CSCs) with enhanced tumorigenicity and chemoresistance are believed
to be responsible for treatment failure and tumor relapse in ovarian cancer patients …
to be responsible for treatment failure and tumor relapse in ovarian cancer patients …
Cellular and molecular mechanisms of hepatocellular carcinoma: an update
RN Aravalli, ENK Cressman, CJ Steer - Archives of toxicology, 2013 - Springer
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor that accounts
for~ 80% of all liver cancer cases worldwide. It is a multifactorial disease caused by a variety …
for~ 80% of all liver cancer cases worldwide. It is a multifactorial disease caused by a variety …
Cancer stem cells: acquisition, characteristics, therapeutic implications, targeting strategies and future prospects
Since last two decades, the major cancer research has focused on understanding the
characteristic properties and mechanism of formation of Cancer stem cells (CSCs), due to …
characteristic properties and mechanism of formation of Cancer stem cells (CSCs), due to …
[HTML][HTML] The promise of nanoparticles-based radiotherapy in cancer treatment
Simple Summary Radiotherapy (RT) is used worldwide as a gold standard treatment
approach for cancer management. However, the RT treatment modality contains limitations …
approach for cancer management. However, the RT treatment modality contains limitations …