Lactic acid: no longer an inert and end-product of glycolysis
S Sun, H Li, J Chen, Q Qian - Physiology, 2017 - journals.physiology.org
For decades, lactic acid has been considered a dead-end product of glycolysis. Research in
the last 20+ years has shown otherwise. Through its transporters (MCTs) and receptor …
the last 20+ years has shown otherwise. Through its transporters (MCTs) and receptor …
[HTML][HTML] Calcium signaling in Alzheimer's disease & therapies
Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …
Alzheimer's‐like signaling in brains of COVID‐19 patients
Introduction The mechanisms that lead to cognitive impairment associated with COVID‐19
are not well understood. Methods Brain lysates from control and COVID‐19 patients were …
are not well understood. Methods Brain lysates from control and COVID‐19 patients were …
Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2
Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and
quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle …
quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle …
Structure of a mammalian ryanodine receptor
Ryanodine receptors (RyRs) mediate the rapid release of calcium (Ca2+) from intracellular
stores into the cytosol, which is essential for numerous cellular functions including excitation …
stores into the cytosol, which is essential for numerous cellular functions including excitation …
Cellular proteostasis in neurodegeneration
The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated
through a vast network of biochemical pathways. This requires the regulated control of …
through a vast network of biochemical pathways. This requires the regulated control of …
Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target
Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …
essential cellular functions, including cardiac and skeletal muscle contraction. The …
[HTML][HTML] Axonal endoplasmic reticulum Ca2+ content controls release probability in CNS nerve terminals
Although the endoplasmic reticulum (ER) extends throughout axons and axonal ER
dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is …
dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is …
Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies
C Finsterwald, CM Alberini - Neurobiology of learning and memory, 2014 - Elsevier
A proper response against stressors is critical for survival. In mammals, the stress response
is primarily mediated by secretion of glucocorticoids via the hypothalamic–pituitary …
is primarily mediated by secretion of glucocorticoids via the hypothalamic–pituitary …
Intracellular Ca2+ signaling and Ca2+ microdomains in the control of cell survival, apoptosis and autophagy
RML La Rovere, G Roest, G Bultynck, JB Parys - Cell calcium, 2016 - Elsevier
The endoplasmic reticulum (ER), mitochondria and lysosomes are physically and/or
functionally linked, establishing close contact sites between these organelles. As a …
functionally linked, establishing close contact sites between these organelles. As a …