Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the 29
causative pathogen of Coronavirus disease 2019 (COVID-19), has resulted in over 650 30 …

The gut has been proposed as a potential alternative entry route for SARS-CoV-2. This was
mainly based on the high levels of SARS-CoV-2 receptor expressed in the gastrointestinal …

The prolonged immobilization associated with COVID-19 infection and the restrictions
imposed by the pandemic have determined major changes in physical activity and eating …

The adverse outcome pathways (AOPs) were developed to accelerate evidence-based
chemical risk assessment by leveraging data from new approach methodologies. Thanks to …

The COVID-19 pandemic caused by the SARS-CoV-2 virus has led to significant global
health implications. Although the respiratory manifestations of COVID-19 are widely …

Background Emerging evidence reveals that SARS-CoV-2 possesses the capability to
disrupt the gastrointestinal (GI) homeostasis, resulting in the long-term symptoms such as …

Abstract SARS‐CoV‐2, the etiological agent of COVID-19, is devoid of any metabolic
capacity; therefore, it is critical for the viral pathogen to hijack host cellular metabolic …

Introduction The CIAO project was launched in Spring 2020 to address the need to make
sense of the numerous and disparate data available on COVID-19 pathogenesis. Based on …

Animal experimentation has been integral to drug discovery and development and safety
assessment for many years, since it provides insights into the mechanisms of drug efficacy …

Immunothrombosis, an excessive inflammatory response with simultaneous overactivation
of the coagulation system, is a central pathomechanism in sepsis and COVID-19. It is …