Quinoline is a versatile pharmacophore, a privileged scaffold and an outstanding fused
heterocyclic compound with a wide range of pharmacological prospective such as …

Quinoline is an efficient scaffold for anticancer drug development as its derivatives have
shown potent results through several mechanisms like growth regulators through “apoptosis …

Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical
structures that confer them with a broad spectrum of pharmacological activities. They have …

Three Cu (II) complexes of quinoline derivatives as cancer chemodynamic therapy agents
were synthesized and characterized. These complexes were heavily taken up by cells and …

A new series of benzo-and tetrahydro benzo-[h] quinoline bearing a flexible (dimethylamino)
ethylcarboxamide side chain was designed and synthesized as DNA-intercalating antitumor …

Protein kinase dysregulation was strongly linked to cancer pathogenesis. Moreover, histone
alterations were found to be among of the most important post-translational modifications …

A series of amide anthraquinone derivatives, an important component of some traditional
Chinese medicines, were structurally modified and the resulting antitumor activities were …

Chemotherapy has been a standard intervention for a variety of cancers to impede tumor
growth, mainly by inducing apoptosis. However, development of resistance to this regimen …

Cancer therapy is based on the selective clearance of malignant cells without severely
damaging healthy tissues, and current clinical practice is constantly in need for new …

Rho-associated protein kinases (ROCKs) are ubiquitously expressed in most adult tissues,
and are involved in modulating the cytoskeleton, protein synthesis and degradation …