Recent advances in biomaterial-boosted adoptive cell therapy
Adoptive immunotherapies based on the transfer of functional immune cells hold great
promise in treating a wide range of malignant diseases, especially cancers, autoimmune …
promise in treating a wide range of malignant diseases, especially cancers, autoimmune …
Particle-Based Artificial Antigen-Presenting Cell Systems for T Cell Activation in Adoptive T Cell Therapy
T cell-based adoptive cell therapy (ACT) has emerged as a promising treatment for various
diseases, particularly cancers. Unlike other immunotherapy modalities, ACT involves directly …
diseases, particularly cancers. Unlike other immunotherapy modalities, ACT involves directly …
Direct in vivo activation of T cells with nanosized immunofilaments inhibits tumor growth and metastasis
L Weiss, J Weiden, Y Dölen, EM Grad… - Acs Nano, 2023 - ACS Publications
Adoptive T cell therapy has successfully been implemented for the treatment of cancer.
Nevertheless, ex vivo expansion of T cells by artificial antigen-presenting cells (aAPCs) …
Nevertheless, ex vivo expansion of T cells by artificial antigen-presenting cells (aAPCs) …
In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles
Simultaneous delivery of mRNA to multiple populations of antigen (Ag)–specific CD8+ T
cells is challenging given the diversity of peptide epitopes and polymorphism of class I major …
cells is challenging given the diversity of peptide epitopes and polymorphism of class I major …
Process development for adoptive cell therapy in academia: a pipeline for clinical-scale manufacturing of multiple TCR-T cell products
Cellular immunotherapies based on T cell receptor (TCR) transfer are promising
approaches for the treatment of cancer and chronic viral infections. The discovery of novel …
approaches for the treatment of cancer and chronic viral infections. The discovery of novel …
Antigen‐Specific Stimulation and Expansion of CAR‐T Cells Using Membrane Vesicles as Target Cell Surrogates
V Ukrainskaya, Y Rubtsov, D Pershin, N Podoplelova… - Small, 2021 - Wiley Online Library
Abstract Development of CAR‐T therapy led to immediate success in the treatment of B cell
leukemia. Manufacturing of therapy‐competent functional CAR‐T cells needs robust …
leukemia. Manufacturing of therapy‐competent functional CAR‐T cells needs robust …
Bioengineering lipid-based synthetic cells for therapeutic protein delivery
S Siquenique, S Ackerman, A Schroeder… - Trends in …, 2024 - cell.com
Synthetic cells (SCs) offer a promising approach for therapeutic protein delivery, combining
principles from synthetic biology and drug delivery. Engineered to mimic natural cells, SCs …
principles from synthetic biology and drug delivery. Engineered to mimic natural cells, SCs …
In vivo gene delivery to immune cells
Highlights•Immune cell therapies are a new class of treatments for complex human
diseases.•Engineering immune cells in vivo can improve manufacturing, efficacy, and …
diseases.•Engineering immune cells in vivo can improve manufacturing, efficacy, and …
[HTML][HTML] Biomaterial-enhanced treg cell immunotherapy: A promising approach for transplant medicine and autoimmune disease treatment
Regulatory T cells (Tregs) are crucial for preserving tolerance in the body, rendering Treg
immunotherapy a promising treatment option for both organ transplants and autoimmune …
immunotherapy a promising treatment option for both organ transplants and autoimmune …
Eliciting an immunostimulatory tumor microenvironment to enhance the antitumor efficacy by targeted cancer immunotherapy
YX Zhang, JJ Zhang, W Wang, XY Guo… - Advanced …, 2022 - Wiley Online Library
Tumor‐associated macrophages (TAMs) in tumor microenvironment represent an ideal
therapeutic target for cancer immunotherapy. A targeted cancer immunotherapy strategy …
therapeutic target for cancer immunotherapy. A targeted cancer immunotherapy strategy …