Abnormal accumulation of proteinaceous intraneuronal inclusions called Lewy bodies (LBs)
is the neurpathological hallmark of Parkinson's disease (PD) and related synucleinopathies …

Defects in membrane trafficking are hallmarks of neurodegeneration. Rab GTPases are key
regulators of membrane trafficking. Alterations of Rab GTPases, or the membrane …

Parkinson's disease (PD) is a common neurodegenerative disorder with prominent loss of
nigro‐striatal dopaminergic neurons. The resultant dopamine (DA) deficiency underlies the …

Alpha-synuclein is a small neuronal protein that is closely associated with the etiology of
Parkinson's disease. Mutations in and alterations in expression levels of alpha-synuclein …

Cholesterol is a critical component of membrane bilayers where it plays key structural and
functional roles by regulating the activity of diverse signaling platforms and pathways …

Synucleinopathies are a group of disorders characterized by the accumulation of inclusions
rich in the a‐synuclein (aSyn) protein. This group of disorders includes Parkinson's disease …

Rab proteins compose the largest family of small GTPases and control the different steps of
intracellular membrane traffic. More recently, they have been shown to also regulate cell …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder with pathological
features including death of dopaminergic neurons in the substantia nigra and intraneuronal …

Genetic variation in the leucine-rich repeat kinase 2 (LRRK2) gene is associated with risk of
familial and sporadic Parkinson's disease (PD). To support clinical development of LRRK2 …

Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous
inclusions represents the key histophathological hallmark of a spectrum of …