Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19

RT Eastman, JS Roth, KR Brimacombe… - ACS central …, 2020 - ACS Publications
The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven
the biomedical community to action—to uncover and develop antiviral interventions. One …

Modulatory effects of probiotics during pathogenic infections with emphasis on immune regulation

A Raheem, L Liang, G Zhang, S Cui - Frontiers in immunology, 2021 - frontiersin.org
In order to inhibit pathogenic complications and to enhance animal and poultry growth,
antibiotics have been extensively used for many years. Antibiotics applications not only …

Nucleotide analogues as inhibitors of SARS-CoV-2 polymerase, a key drug target for COVID-19

M Chien, TK Anderson, S Jockusch, C Tao… - Journal of proteome …, 2020 - ACS Publications
SARS-CoV-2 is responsible for the current COVID-19 pandemic. On the basis of our
analysis of hepatitis C virus and coronavirus replication, and the molecular structures and …

Nutritional status, diet and viral respiratory infections: perspectives for severe acute respiratory syndrome coronavirus 2

AH de Araújo Morais, J de Souza Aquino… - British Journal of …, 2021 - cambridge.org
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was
recognised by the WHO as a pandemic in 2020. Host preparation to combat the virus is an …

Clinical characteristics, risk factors, and incidence of symptomatic coronavirus disease 2019 in a large cohort of adults living with HIV: a single-center, prospective …

A Inciarte, A Gonzalez-Cordon, J Rojas, B Torres… - Aids, 2020 - journals.lww.com
Background: It is unclear how characteristics, risk factors, and incidence of coronavirus
disease 2019 (COVID-19) in people living with HIV (PLWH) differ from the general …

Repurposing drugs, ongoing vaccine, and new therapeutic development initiatives against COVID-19

RP Saha, AR Sharma, MK Singh, S Samanta… - Frontiers in …, 2020 - frontiersin.org
As the COVID-19 is still growing throughout the globe, a thorough investigation into the
specific immunopathology of SARS-CoV-2, its interaction with the host immune system and …

The impact of sofosbuvir/daclatasvir or ribavirin in patients with severe COVID-19

G Eslami, S Mousaviasl, E Radmanesh… - Journal of …, 2020 - academic.oup.com
Objectives Sofosbuvir and daclatasvir are direct-acting antivirals highly effective against
hepatitis C virus. There is some in silico and in vitro evidence that suggests these agents …

A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19

S Jockusch, C Tao, X Li, TK Anderson, M Chien… - Antiviral research, 2020 - Elsevier
Abstract SARS-CoV-2, a member of the coronavirus family, is responsible for the current
COVID-19 worldwide pandemic. We previously demonstrated that five nucleotide analogues …

[HTML][HTML] A comprehensive review on pharmacologic agents, immunotherapies and supportive therapeutics for COVID-19

K Sharun, R Tiwari, MI Yatoo, S Natesan, D Megawati… - Narra J, 2022 - ncbi.nlm.nih.gov
The emergence of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected many countries throughout …

Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir

S Jockusch, C Tao, X Li, M Chien, S Kumar… - Scientific reports, 2020 - nature.com
SARS-CoV-2 is responsible for COVID-19, resulting in the largest pandemic in over a
hundred years. After examining the molecular structures and activities of hepatitis C viral …