Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …

The tumor microenvironment (TME) is composed of many different cellular and acellular
components that together drive tumor growth, invasion, metastasis, and response to …

Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …

Spatial molecular profiling of complex tissues is essential to investigate cellular function in
physiological and pathological states. However, methods for molecular analysis of large …

The completion of the Human Genome Project has provided a foundational blueprint for
understanding human life. Nonetheless, understanding the intricate mechanisms through …

The RNA modification N6-methyladenosine (m6A) regulates the interaction between RNA
and various RNA binding proteins within the nucleus and other subcellular compartments …

Single-cell technologies have been known as advanced and powerful tools to study tumor
biological systems at the single-cell resolution and are playing increasingly critical roles in …

The central nervous system (CNS) contains a diverse number of neuronal and non-neuronal
cell types that physically interact with one another. It is these physical interactions which …

With the aim of producing a 3D representation of tumors, imaging and molecular annotation
of xenografts and tumors (IMAXT) uses a large variety of modalities in order to acquire tumor …

Techniques for single-cell and spatial expression profiling hold great promise for defining
the complexity of metastatic microenvironments, but different methods give different …