Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of
cell death caused by the accumulation of lipid-based reactive oxygen species; this type of …

Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron
metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria …

Ferroptosis is a new form of nonapoptotic programmed cell death characterized by iron-
dependent accumulation of lipid hydroperoxides to lethal levels. An increasing number of …

Selenium (Se) is an essential micronutrient that has several important functions in animal
and human health. The biological functions of Se are carried out by selenoproteins …

Objective To investigate the effects of high intensity interval training (HIIT) on the maternal
heart, fetuses and placentas of pregnant rats. Methods Female Sprague-Dawley rats were …

The response to hypoxia is primarily mediated by the hypoxia-inducible transcription factor
(HIF). Levels of HIF are regulated by the oxygen-sensing HIF hydroxylases, members of the …

Nonalcoholic fatty liver disease (NAFLD), characterized by ectopic fat accumulation in
hepatocytes, is closely linked to insulin resistance and is the most frequent complication of …

Abnormal heart development is a key feature contributing to the cardiac defects of
congenital heart diseases, which are the most common birth defects in humans, occurring in …

Embryonic development involves dramatic changes in cell proliferation and differentiation
that must be highly coordinated and tightly regulated. Cellular redox balance is critical for …