The C3 glomerulopathies are a group of rare kidney diseases characterized by complement
dysregulation occurring in the fluid phase and in the glomerular microenvironment, which …

The factor H (FH) protein family is emerging as a complex network of proteins controlling the
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …

Dense deposit disease and glomerulonephritis with isolated C3 deposits are
glomerulopathies characterized by deposits of C3 within or along the glomerular basement …

Background Age-related macular degeneration is the most common cause of blindness in
Western populations. Susceptibility is influenced by age and by genetic and environmental …

The complement system is an essential component of the innate immune system that
participates in elimination of pathogens and altered host cells and comprises an essential …

Factor H is an essential regulatory protein that plays a critical role in the homeostasis of the
complement system in plasma and in the protection of bystander host cells and tissues from …

The alternative pathway of complement is activated continuously in vivo through the C3'tick-
over'pathway 1. This pathway is triggered by the hydrolysis of C3, resulting in the formation …

The complement system is increasingly recognized as important in the pathogenesis of
tissue injury in vivo following immune, ischemic, or infectious insults. Within the complement …

There are many links between the complement system and the autoimmune disease
systemic lupus erythematosus (SLE). Soon after the identification of antinuclear antibodies …

The complement system has developed a remarkably simple but elegant manner of
regulating itself. It has faced and successfully dealt with how to facilitate activation on a …