Pubertal development and regulation
Puberty marks the end of childhood and is a period when individuals undergo physiological
and psychological changes to achieve sexual maturation and fertility. The hypothalamic …
and psychological changes to achieve sexual maturation and fertility. The hypothalamic …
[HTML][HTML] Prader-Willi syndrome: a review of clinical, genetic, and endocrine findings
MA Angulo, MG Butler, ME Cataletto - Journal of endocrinological …, 2015 - Springer
Abstract Introduction Prader-Willi syndrome (PWS) is a multisystemic complex genetic
disorder caused by lack of expression of genes on the paternally inherited chromosome …
disorder caused by lack of expression of genes on the paternally inherited chromosome …
Causes, diagnosis, and treatment of central precocious puberty
AC Latronico, VN Brito, JC Carel - The lancet Diabetes & …, 2016 - thelancet.com
Central precocious puberty results from the premature activation of the hypothalamic-
pituitary-gonadal axis. It mimics physiological pubertal development, although at an …
pituitary-gonadal axis. It mimics physiological pubertal development, although at an …
Diagnosis and management of precocious sexual maturation: an updated review
AV Cheuiche, LG da Silveira, LCP de Paula… - European Journal of …, 2021 - Springer
The classic definition of precocious sexual maturation is the development of secondary
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …
[HTML][HTML] MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons
The identification of loss-of-function mutations in MKRN3 in patients with central precocious
puberty in association with the decrease in MKRN3 expression in the medial basal …
puberty in association with the decrease in MKRN3 expression in the medial basal …
The congenital and acquired mechanisms implicated in the etiology of central precocious puberty
The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …
congenital and acquired causes that can be associated with structural or functional brain …
Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty
A Dauber, M Cunha-Silva, DB Macedo… - The Journal of …, 2017 - academic.oup.com
Context: Central precocious puberty (CPP) results from premature activation of the
hypothalamic–pituitary–gonadal axis. Few genetic causes of CPP have been identified, with …
hypothalamic–pituitary–gonadal axis. Few genetic causes of CPP have been identified, with …
GENETICS IN ENDOCRINOLOGY: Genetic etiologies of central precocious puberty and the role of imprinted genes
SA Roberts, UB Kaiser - European Journal of Endocrinology, 2020 - academic.oup.com
Pubertal timing is regulated by the complex interplay of genetic, environmental, nutritional
and epigenetic factors. Criteria for determining normal pubertal timing, and thus the …
and epigenetic factors. Criteria for determining normal pubertal timing, and thus the …
[HTML][HTML] Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted loci
T Eggermann, G Perez de Nanclares, ER Maher… - Clinical …, 2015 - Springer
Congenital imprinting disorders (IDs) are characterised by molecular changes affecting
imprinted chromosomal regions and genes, ie genes that are expressed in a parent-of-origin …
imprinted chromosomal regions and genes, ie genes that are expressed in a parent-of-origin …
Central precocious puberty: Recent advances in understanding the aetiology and in the clinical approach
Central precocious puberty (CPP) results from early activation of the hypothalamic‐pituitary‐
gonadal (HPG) axis. The current state of knowledge of the complex neural network acting at …
gonadal (HPG) axis. The current state of knowledge of the complex neural network acting at …