Puberty marks the end of childhood and is a period when individuals undergo physiological
and psychological changes to achieve sexual maturation and fertility. The hypothalamic …

Abstract Introduction Prader-Willi syndrome (PWS) is a multisystemic complex genetic
disorder caused by lack of expression of genes on the paternally inherited chromosome …

Central precocious puberty results from the premature activation of the hypothalamic-
pituitary-gonadal axis. It mimics physiological pubertal development, although at an …

The classic definition of precocious sexual maturation is the development of secondary
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …

The identification of loss-of-function mutations in MKRN3 in patients with central precocious
puberty in association with the decrease in MKRN3 expression in the medial basal …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Context: Central precocious puberty (CPP) results from premature activation of the
hypothalamic–pituitary–gonadal axis. Few genetic causes of CPP have been identified, with …

Pubertal timing is regulated by the complex interplay of genetic, environmental, nutritional
and epigenetic factors. Criteria for determining normal pubertal timing, and thus the …

Congenital imprinting disorders (IDs) are characterised by molecular changes affecting
imprinted chromosomal regions and genes, ie genes that are expressed in a parent-of-origin …

Central precocious puberty (CPP) results from early activation of the hypothalamic‐pituitary‐
gonadal (HPG) axis. The current state of knowledge of the complex neural network acting at …