Alcohol-associated liver disease (ALD) is a common chronic liver disease with increasing
incidence worldwide. Alcoholic liver steatosis/steatohepatitis can progress to liver …

Heavy alcohol intake induces a wide spectrum of liver diseases ranging from steatosis,
steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Although alcohol …

The first seven members of the proprotein convertase (PC) family activate protein precursors
by cleavage after basic residues. While PC7 has no known specific substrates, it shows …

Binge drinking, ie, heavy episodic drinking in a short time, has recently become an alarming
societal problem with negative health impact. However, the harmful effects of acute alcohol …

Triptolide (TP), a major component of TWHF, is widely used to treat rheumatoid arthritis,
systemic lupus erythematosus, nephritis and leprosy. However, its clinical use is limited by …

Acetaminophen (APAP) overdose is the major cause of drug-induced liver injury and acute
liver failure. Approximately 10% of APAP is metabolized by cytochrome P450 (CYP2E1) into …

The human HepaRG cell line has been established from a hepatocholangiocarcinoma and
first described in 2002; it possesses bipotent properties allowing commitment into two cell …

The development of alcoholic liver diseases depends on the ability of hepatocyte to
proliferate and differentiate in the case of alcohol-induced injury. Our previous work showed …

Two pools of caseinophosphopeptides (CPPs) obtained from αs-and β-casein fractions (α-
CPPs and β-CPPs) were characterized. A total of 16 CPPs were identified in the α-CPPs …

Alcohol abuse is a major cause of pancreatitis. However alcohol toxicity has not been fully
elucidated in the pancreas and little is known about the effect of alcohol on pancreatic ducts …