The β-cell/EC axis: how do islet cells talk to each other?
Within the pancreatic islet, the β-cell represents the ultimate biosensor. Its central function is
to accurately sense glucose levels in the blood and consequently release appropriate …
to accurately sense glucose levels in the blood and consequently release appropriate …
[HTML][HTML] Gap junction proteins are key drivers of endocrine function
P Meda - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2018 - Elsevier
It has long been known that the main secretory cells of exocrine and endocrine glands are
connected by gap junctions, made by a variety of connexin species that ensure their …
connected by gap junctions, made by a variety of connexin species that ensure their …
Protein‐mediated interactions of pancreatic islet cells
P Meda - Scientifica, 2013 - Wiley Online Library
The islets of Langerhans collectively form the endocrine pancreas, the organ that is soley
responsible for insulin secretion in mammals, and which plays a prominent role in the …
responsible for insulin secretion in mammals, and which plays a prominent role in the …
Connexins and β-cell functions
V Cigliola, V Chellakudam, W Arabieter… - Diabetes research and …, 2013 - Elsevier
Proper functioning of pancreatic islets requires that numerous β-cells are properly
coordinated. With evolution, many mechanisms have converged, which now allow individual …
coordinated. With evolution, many mechanisms have converged, which now allow individual …
Roles of connexins and pannexins in (neuro) endocrine physiology
To ensure appropriate secretion in response to demand,(neuro) endocrine tissues liberate
massive quantities of hormones, which act to coordinate and synchronize biological signals …
massive quantities of hormones, which act to coordinate and synchronize biological signals …
Expression of the gap junction protein connexin36 in small intensely fluorescent (SIF) cells in cardiac parasympathetic ganglia of rodents
P Singhal, JMM Senecal, JI Nagy - Neuroscience Letters, 2023 - Elsevier
In mammals, several endocrine cell types are electrically coupled by connexin36 (Cx36)-
containing gap junctions, which mediate intercellular communication and allow regulated …
containing gap junctions, which mediate intercellular communication and allow regulated …
Restoration of connexin 40 (Cx40) in Renin-producing cells reduces the hypertension of Cx40 null mice
Connexin 40 (Cx40) is expressed by the renin-producing cells (RSCs) of the kidneys and
the endothelial cells of blood vessels. Cx40 null mice (Cx40−/−) feature a much increased …
the endothelial cells of blood vessels. Cx40 null mice (Cx40−/−) feature a much increased …
Learning theories reveal loss of pancreatic electrical connectivity in diabetes as an adaptive response
Cells of almost all solid tissues are connected with gap junctions which permit the direct
transfer of ions and small molecules, integral to regulating coordinated function in the tissue …
transfer of ions and small molecules, integral to regulating coordinated function in the tissue …
The Role of the Gap Junction Protein Connexin in Adrenal Gland Tumorigenesis
M Mizdrak, T Ticinovic Kurir, I Mizdrak… - International Journal of …, 2024 - mdpi.com
Gap junctions (GJs) are important in the regulation of cell growth, morphology, differentiation
and migration. However, recently, more attention has been paid to their role in the …
and migration. However, recently, more attention has been paid to their role in the …
Role of connexins and pannexins in the pancreas
V Cigliola, F Allagnat, LA Berchtold, S Lamprianou… - Pancreas, 2015 - journals.lww.com
The pancreas produces enzymes with a digestive function and hormones with a metabolic
function, which are produced by distinct cell types of acini and islets, respectively. Within …
function, which are produced by distinct cell types of acini and islets, respectively. Within …