Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments

GOB Ghanem, LK Wareham, DJ Calkins - Progress in Retinal and Eye …, 2024 - Elsevier
Glaucoma is the leading cause of irreversible blindness globally. The disease causes vision
loss due to neurodegeneration of the retinal ganglion cell (RGC) projection to the brain …

Supplementation with l-arginine and nitrates vs age and individual physiological reactivity

N Kurhaluk - Nutrition Reviews, 2023 - academic.oup.com
Ageing is a natural ontogenetic phenomenon that entails a decrease in the adaptive
capacity of the organism, as a result of which the body becomes less adaptable to stressful …

[HTML][HTML] Retinal astrocyte morphology predicts integration of vascular and neuronal architecture

JM Holden, LK Wareham, DJ Calkins - Frontiers in Neuroscience, 2023 - frontiersin.org
Astrocytes are important regulators of blood flow and play a key role in the response to injury
and disease in the central nervous system (CNS). Despite having an understanding that …

cGMP Signaling in the Neurovascular Unit—Implications for Retinal Ganglion Cell Survival in Glaucoma

AA Haider, TS Rex, LK Wareham - Biomolecules, 2022 - mdpi.com
Glaucoma is a progressive age-related disease of the visual system and the leading cause
of irreversible blindness worldwide. Currently, intraocular pressure (IOP) is the only …

cGMP signaling: a potential therapeutic target for neurodegeneration in glaucoma?

JM Holden, LK Wareham - Neural Regeneration Research, 2023 - journals.lww.com
Neurodegeneration of the central nervous system (CNS) underscores many of humanity's
most debilitating diseases, including Alzheimer's disease, Parkinson's disease, and multiple …

Morphological and electrophysiological characterization of a novel displaced astrocyte in the mouse retina

JM Holden, LK Wareham, DJ Calkins - Glia, 2024 - Wiley Online Library
Astrocytes throughout the central nervous system are heterogeneous in both structure and
function. This diversity leads to tissue‐specific specialization where morphology is adapted …

功能失调的cGMP 信号传导导致小鼠与年龄相关的视网膜血管改变和星形胶质细胞重塑

JM Holden, LK Wareham - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
Neurodegeneration of the central nervous system (CNS) underscores many of humanity's
most debilitating diseases, including Alzheimer's disease, Parkinson's disease, and multiple …