Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in Streptomyces genomes
Covering: 2010 to 2020 Over the last few decades, Streptomyces have been extensively
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …
[HTML][HTML] Streptomyces as Microbial Chassis for Heterologous Protein Expression
Heterologous production of recombinant proteins is gaining increasing interest in
biotechnology with respect to productivity, scalability, and wide applicability. The members …
biotechnology with respect to productivity, scalability, and wide applicability. The members …
[HTML][HTML] Prospective bacterial and fungal sources of hyaluronic acid: A review
EV Shikina, RA Kovalevsky, AI Shirkovskaya… - Computational and …, 2022 - Elsevier
The unique biological and rheological properties make hyaluronic acid a sought-after
material for medicine and cosmetology. Due to very high purity requirements for hyaluronic …
material for medicine and cosmetology. Due to very high purity requirements for hyaluronic …
The design-build-test-learn cycle for metabolic engineering of streptomycetes
Streptomycetes are producers of a wide range of specialized metabolites of great medicinal
and industrial importance, such as antibiotics, antifungals, or pesticides. Having been the …
and industrial importance, such as antibiotics, antifungals, or pesticides. Having been the …
[HTML][HTML] RiboRid: A low cost, advanced, and ultra-efficient method to remove ribosomal RNA for bacterial transcriptomics
RNA sequencing techniques have enabled the systematic elucidation of gene expression
(RNA-Seq), transcription start sites (differential RNA-Seq), transcript 3′ ends (Term-Seq) …
(RNA-Seq), transcription start sites (differential RNA-Seq), transcript 3′ ends (Term-Seq) …
A comparative metabologenomic approach reveals mechanistic insights into Streptomyces antibiotic crypticity
Y Qi, KK Nepal, JAV Blodgett - Proceedings of the National …, 2021 - National Acad Sciences
Streptomyces genomes harbor numerous, biosynthetic gene clusters (BGCs) encoding for
drug-like compounds. While some of these BGCs readily yield expected products, many do …
drug-like compounds. While some of these BGCs readily yield expected products, many do …
Development of highly characterized genetic bioparts for efficient gene expression in CO2-fixing Eubacterium limosum
Acetogenic bacteria demonstrate industrial potential for utilizing carbon dioxide (CO 2) for
biochemical production using the Wood-Ljungdahl pathway. However, the metabolic …
biochemical production using the Wood-Ljungdahl pathway. However, the metabolic …
Different Regulatory Modes of Synechocystis sp. PCC 6803 in Response to Photosynthesis Inhibitory Conditions
Cyanobacteria are promising industrial platforms owing to their ability to produce diverse
natural secondary metabolites and nonnative value-added biochemicals from CO2 and light …
natural secondary metabolites and nonnative value-added biochemicals from CO2 and light …
[HTML][HTML] Transcriptome and translatome profiles of Streptomyces species in different growth phases
Streptomyces are efficient producers of various bioactive compounds, which are mostly
synthesized by their secondary metabolite biosynthetic gene clusters (smBGCs). The …
synthesized by their secondary metabolite biosynthetic gene clusters (smBGCs). The …
Synthetic 3′-UTR valves for optimal metabolic flux control in Escherichia coli
As the design of genetic circuitry for synthetic biology becomes more sophisticated, diverse
regulatory bioparts are required. Despite their importance, well-characterized 3 …
regulatory bioparts are required. Despite their importance, well-characterized 3 …