Chronic pain is a highly prevalent debilitating condition for which treatment options remain
limited for many patients. Ionotropic ATP signalling through excitatory and calcium …

Migraine is a chronic neurological disorder that affects approximately 12% of the population.
The cause of migraine headaches is not yet known, however, when the trigeminal system is …

Oral cancer patients report sensitivity to spicy foods and liquids. The mechanism responsible
for chemosensitivity induced by oral cancer is not known. We simulate oral cancer-induced …

Purpose: Persistent ocular surface pain occurs in moderate to severe dry eye disease (DE);
however, the mechanisms that underlie this symptom remain uncertain. The aim of this study …

Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that is
intensively expressed in the peripheral nerve system and involved in a variety of …

Most pharmaceutical companies test their discovery-stage proprietary molecules in a battery
of in vitro pharmacology assays to try to determine off-target interactions. During all phases …

Central nervous system (CNS) diseases can lead to motor, sensory, speech, cognitive
dysfunction, and sometimes even death. These diseases are recognized to cause a …

Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is expressed in
muscle afferents and direct activation of these receptors induces acute mechanical …

Transient receptor potential vanilloid 1 (TRPV1) is a transmembrane and non-selective
cation channel protein, which can be activated by various physical and chemical stimuli …

Highlights•Men and women experience muscle pain differently. The underlying mechanisms
for this difference are still not fully understood.•Peripheral mechanisms of muscle pain …