Amelogenesis imperfecta (AI) is the name given to a heterogeneous group of conditions
characterized by inherited developmental enamel defects. AI enamel is abnormally thin, soft …

Amelogenesis imperfecta (AI) represents a group of developmental conditions, genomic in
origin, which affect the structure and clinical appearance of enamel of all or nearly all the …

Dental anomalies are caused by complex interactions between genetic, epigenetic and
environmental factors during the long process of dental development. This process is …

Enamel is a hard nanocomposite bioceramic with significant resilience that protects the
mammalian tooth from external physical and chemical damages. The remarkable …

Amelogenesis imperfecta (AI) is a heterogeneous group of genetic rare diseases disrupting
enamel development (Smith et al., Front Physiol, 2017a, 8, 333). The clinical enamel …

Dental enamel is the epithelial-derived hard tissue covering the crowns of teeth. It is the
most highly mineralized and hardest tissue in the body. Dental enamel is acellular and has …

The genetic control of dental development represents a complex series of events, which can
very schematically be divided in two pathways: specification of type, size and position of …

Enamelin is critical for proper dental enamel formation, and defects in the human enamelin
gene cause autosomal dominant amelogenesis imperfecta. We used gene targeting to …

In humans, inherited variation in the number, size, and shape of teeth within the dentitions
are relatively common, while rarer defects of hard tissue formation, including amelogenesis …

Structured Abstract Authors–Hu JC‐C, Simmer JP The synthesis of tooth development
biology with human studies focusing on inherited conditions that specifically interfere with …