Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Understanding structural dynamics of biomolecules at the single-molecule level is vital to
advancing our knowledge of molecular mechanisms. Currently, there are few techniques …

The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across
biological membranes. Dysregulation of SLCs has been associated with various …

Solute carrier spinster homolog 2 (SPNS2), one of only four known major facilitator
superfamily (MFS) lysolipid transporters in humans, exports sphingosine-1-phosphate (S1P) …

Secondary transporters undergo structural rearrangements to catalyze substrate
translocation across the cell membrane–yet how such conformational changes happen …

Highlights•Simulations provide a computational tool to probe membrane structure and
dynamics.•Simulations can successfully predict lipid binding sites on membrane …

Lipid molecules are able to selectively interact with specific sites on integral membrane
proteins, and modulate their structure and function. Identification and characterization of …

Membranes are known to have modulatory effects on G protein-coupled receptors (GPCRs)
via specific lipid interactions. However, the mechanisms of such modulations in …