Considerations for the use of phage therapy in clinical practice

GA Suh, TP Lodise, PD Tamma… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Increasing antimicrobial resistance and medical device-related infections have led to a
renewed interest in phage therapy as an alternative or adjunct to conventional …

Phage engineering and phage‐assisted CRISPR‐Cas delivery to combat multidrug‐resistant pathogens

K Khambhati, G Bhattacharjee, N Gohil… - Bioengineering & …, 2023 - Wiley Online Library
Antibiotic resistance ranks among the top threats to humanity. Due to the frequent use of
antibiotics, society is facing a high prevalence of multidrug resistant pathogens, which have …

The current status of phage therapy and its advancement towards establishing standard antimicrobials for combating multi drug-resistant bacterial pathogens

Y Ali, I Inusa, G Sanghvi, VB Mandaliya… - Microbial Pathogenesis, 2023 - Elsevier
Phage therapy; a revived antimicrobial weapon, has great therapeutic advantages with the
main ones being its ability to eradicate multidrug-resistant pathogens as well as selective …

Polysaccharide-based hydrogels for drug delivery and wound management: a review

D Sanjanwala, V Londhe, R Trivedi… - Expert Opinion on …, 2022 - Taylor & Francis
ABSTRACT Introduction Polysaccharide-based hydrogels (PBHs) offer several advantages
over their synthetic counterparts. Their natural origin contributes to their nontoxicity, high …

[HTML][HTML] Design of Phage-Cocktail–Containing Hydrogel for the Treatment of Pseudomonas aeruginosa–Infected Wounds

F Shafigh Kheljan, F Sheikhzadeh Hesari… - Viruses, 2023 - mdpi.com
Recently, the treatment of infected wounds has become a global problem due to increased
antibiotic resistance in bacteria. The Gram-negative opportunistic pathogen Pseudomonas …

Advancements in bacteriophage therapies and delivery for bacterial infection

HA Durr, ND Leipzig - Materials Advances, 2023 - pubs.rsc.org
Having co-evolved with bacteria over hundreds of millions of years, bacteriophage are
effective killers of specific bacterial hosts. Therefore, phage therapies for infection are a …

[HTML][HTML] A comprehensive review on phage therapy and phage-based drug development

L Cui, S Watanabe, K Miyanaga, K Kiga, T Sasahara… - Antibiotics, 2024 - mdpi.com
Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining
momentum as a promising weapon against the rising threat of multidrug-resistant (MDR) …

Alginate microbeads and hydrogels delivering meropenem and bacteriophages to treat Pseudomonas aeruginosa fracture-related infections

B Chen, LP Benavente, M Chittò… - Journal of Controlled …, 2023 - Elsevier
Bacteriophage (phage) therapy has shown promise in treating fracture-related infection
(FRI); however, questions remain regarding phage efficacy against biofilms, phage-antibiotic …

Antimicrobial strategies for topical biofilm-based wound infections: past, present, and future

RK Thapa, JO Kim, J Kim - Journal of Pharmaceutical Investigation, 2023 - Springer
Background Chronic wound infections are a serious global health concern affecting millions
of people. One of the major challenges in treating biofilm-based wound infections is the …

Pharmacokinetics and pharmacodynamics of bacteriophage therapy: a review with a focus on multidrug-resistant Gram-negative bacterial infections

M Siopi, D Skliros, P Paranos, N Koumasi… - Clinical Microbiology …, 2024 - journals.asm.org
Despite the early recognition of their therapeutic potential and the current escalation of
multidrug-resistant (MDR) pathogens, the adoption of bacteriophages into mainstream …