Hair cell toxicology: with the help of a little fish

A Barrallo-Gimeno, J Llorens - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Hearing or balance loss are disabling conditions that have a serious impact in those
suffering them, especially when they appear in children. Their ultimate cause is frequently …

The environment to the rescue: can physics help predict predator–prey interactions?

M Cherif, U Brose, MR Hirt, R Ryser, V Silve… - Biological …, 2024 - Wiley Online Library
Understanding the factors that determine the occurrence and strength of ecological
interactions under specific abiotic and biotic conditions is fundamental since many aspects …

[HTML][HTML] SAMPL is a high-throughput solution to study unconstrained vertical behavior in small animals

Y Zhu, F Auer, H Gelnaw, SN Davis, KR Hamling… - Cell reports, 2023 - cell.com
Balance and movement are impaired in many neurological disorders. Recent advances in
behavioral monitoring provide unprecedented access to posture and locomotor kinematics …

Assessing the disparity: comparative toxicity of Copper in zebrafish larvae exposes alarming consequences of permissible concentrations in Brazil

MV Takemura Mariano… - Journal of Toxicology …, 2024 - Taylor & Francis
Copper (Cu) is a naturally occurring metal with essential micronutrient properties. However,
this metal might also pose increased adverse environmental and health risks due to …

Simple Behavioral Analysis (SimBA) as a platform for explainable machine learning in behavioral neuroscience

NL Goodwin, JJ Choong, S Hwang, K Pitts… - Nature …, 2024 - nature.com
The study of complex behaviors is often challenging when using manual annotation due to
the absence of quantifiable behavioral definitions and the subjective nature of behavioral …

High-THC Cannabis smoke impairs incidental memory capacity in spontaneous tests of novelty preference for objects and odors in male rats

IL Barnard, TJ Onofrychuk, AD Toderash, VN Patel… - eneuro, 2023 - eneuro.org
Working memory is an executive function that orchestrates the use of limited amounts of
information, referred to as working memory capacity, in cognitive functions. Cannabis …

Multisensory navigational strategies of hatchling fish for dispersal

A Lin, E Álvarez-Salvado, N Milicic, N Pujara… - Current Biology, 2023 - cell.com
Animals influence how they disperse in the environment by sensing local cues and adapting
how they move. However, controlling dispersal can present a particular challenge early in …

Direct targeting of mitochondria by cisplatin leads to cytotoxicity in zebrafish lateral-line hair cells

DS Lee, A Schrader, J Zou, WH Ang, ME Warchol… - Iscience, 2024 - cell.com
Cisplatin is a chemotherapy drug that causes permanent hearing loss by injuring cochlear
hair cells. Hair cell mitochondria have emerged as potential mediators of hair cell …

Evaluation of cisplatin-induced pathology in the larval zebrafish lateral line

DS Lee, A Schrader, E Bell, ME Warchol… - International journal of …, 2022 - mdpi.com
Cisplatin is an effective anticancer agent, but also causes permanent hearing loss by
damaging hair cells—the sensory receptors essential for hearing. There is an urgent clinical …

A zebrafish gephyrinb mutant distinguishes synaptic and enzymatic functions of Gephyrin

EJ Brennan, KR Monk, J Li - Neural Development, 2024 - Springer
Gephyrin is thought to play a critical role in clustering glycine receptors at synapses within
the central nervous system (CNS). The main in vivo evidence for this comes from Gephyrin …