[HTML][HTML] The distinct roles of sialyltransferases in cancer biology and onco-immunology
M Hugonnet, P Singh, Q Haas… - Frontiers in …, 2021 - frontiersin.org
Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …
The human sialyltransferase family
A Harduin-Lepers, V Vallejo-Ruiz… - Biochimie, 2001 - Elsevier
The human genome encodes probably more than 20 different sialyltransferases involved in
the biosynthesis of sialylated glycoproteins and glycolipids but to date only 15 different …
the biosynthesis of sialylated glycoproteins and glycolipids but to date only 15 different …
MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint
BAH Smith, A Deutzmann, KM Correa… - Proceedings of the …, 2023 - National Acad Sciences
The Siglecs (sialic acid-binding immunoglobulin-like lectins) are glycoimmune checkpoint
receptors that suppress immune cell activation upon engagement of cognate sialoglycan …
receptors that suppress immune cell activation upon engagement of cognate sialoglycan …
[HTML][HTML] Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis: secretion of fibroblast growth factor 23 requires O-glycosylation
K Kato, C Jeanneau, MA Tarp, A Benet-Pages… - Journal of Biological …, 2006 - ASBMB
Mutations in the gene encoding the glycosyltransferase polypeptide GalNAc-T3, which is
involved in initiation of O-glycosylation, were recently identified as a cause of the rare …
involved in initiation of O-glycosylation, were recently identified as a cause of the rare …
Sialyltransferases in cancer
F Dall'Olio, M Chiricolo - Glycoconjugate journal, 2001 - Springer
It has long been known that cancer cells often express more heavily sialylated glycans on
their surface and that this feature sometimes correlates with invasion. It is now well …
their surface and that this feature sometimes correlates with invasion. It is now well …
Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen
Abstract The Sialyl-Tn antigen (Neu5Acα2–6GalNAc-O-Ser/Thr) is highly expressed in
several human carcinomas and is associated with carcinoma aggressiveness and poor …
several human carcinomas and is associated with carcinoma aggressiveness and poor …
Human airway mucin glycosylation: a combinatory of carbohydrate determinants which vary in cystic fibrosis
G Lamblin, S Degroote, JM Perini, P Delmotte… - Glycoconjugate …, 2001 - Springer
Human airway mucins represent a very broad family of polydisperse high molecular mass
glycoproteins, which are part of the airway innate immunity. Apomucins, which correspond to …
glycoproteins, which are part of the airway innate immunity. Apomucins, which correspond to …
[HTML][HTML] Glycogene expression alterations associated with pancreatic cancer epithelial-mesenchymal transition in complementary model systems
Background The ability to selectively detect and target cancer cells that have undergone an
epithelial-mesenchymal transition (EMT) may lead to improved methods to treat cancers …
epithelial-mesenchymal transition (EMT) may lead to improved methods to treat cancers …
[PDF][PDF] Sialyltransferases functions in cancers
A Harduin-Lepers… - … in Bioscience-Elite, 2012 - article.imrpress.com
Introduction 3. Human ST involved in the synthesis of sialylated TACA 3.1. The β-
galactoside α2, 3-sialyltransferases (ST3Gal) 3.2. The β-galactoside α2, 6-sialyltransferases …
galactoside α2, 3-sialyltransferases (ST3Gal) 3.2. The β-galactoside α2, 6-sialyltransferases …
Glycosyltransferases as versatile tools to study the biology of glycans
JM Kofsky, JL Babulic, ME Boddington… - …, 2023 - academic.oup.com
All cells are decorated with complex carbohydrate structures called glycans that serve as
ligands for glycan-binding proteins (GBPs) to mediate a wide range of biological processes …
ligands for glycan-binding proteins (GBPs) to mediate a wide range of biological processes …