Bloodstream infection (BSI) is a major cause of death in developed countries and the
detection of microorganisms is essential in managing patients. Despite major progress has …

Background Bloodstream infection (BSI) is a major public health burden worldwide, with
high mortality. Patient outcome is critically influenced by delayed therapy, and fast and …

We carried out integrated host and pathogen metagenomic RNA and DNA next generation
sequencing (mNGS) of whole blood (n= 221) and plasma (n= 138) from critically ill patients …

Background Despite the development of new microbiologic technologies, blood cultures
(BCs) remain the first-line tool for the diagnosis of bloodstream infections. Their diagnostic …

Bloodstream infections (BSI) have a substantial impact on morbidity and mortality worldwide.
Despite scarcity of data from many low-and middle-income countries (LMICs), there is …

Objective Infections are the major cause of morbidity and mortality in immunocompromised
patients. Improving microbiological diagnosis in these patients is of paramount clinical …

Background Systemic inflammation is a whole body reaction having an infection-positive (ie,
sepsis) or infection-negative origin. It is important to distinguish between these two …

Severe sepsis and septic shock are as common and lethal as other acute life-threatening
conditions that emergency physicians routinely confront such as acute myocardial infarction …

Objective: Early identification of causative microorganism (s) in patients with severe infection
is crucial to optimize antimicrobial use and patient survival. However, current culture-based …

The rapid identification of bacteria and fungi directly from the blood of patients with
suspected bloodstream infections aids in diagnosis and guides treatment decisions. The …